from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1980c/mpt64

LFCtreatmentdescriptionclass of inhibitor

0.173

Amikacinug/mL Amikacintranslation

0.648

Cap5-10ug/mL Capreomycintranslation

0.955

Rox10-50 ug/mL Roxithromycintranslation

0.228

SM2-5 ug/mL Streptomycintranslation

0.484

Tet5-10 ug/mL Tetracyclinetranslation

-0.141

Rif0.2-5ug/mL Rifampicintranscription

-0.738

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.727

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.899

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.462

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.863

Clofazimine10-13 ug/mL Clofaziminerespiration

0.231

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.818

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.920

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.275

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.498

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.505

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.711

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.435

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.316

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.004

KCN5-20 ug/mL Potassium cyaniderespiration

-0.101

NaN30.2-2 mM Sodium aziderespiration

1.041

Nigericin50 uM Nigericinrespiration

-1.040

TRC10-150 ug/mL Triclosanrespiration

-1.643

TRZ10-25 ug/mL Thioridazinerespiration

-0.372

Valinomycin0.5-10 uM Valinomycinrespiration

1.176

ZnSO42 mM ZnSO4respiration

-0.744

menadione6-10 ug/mL Menadionerespiration

-0.233

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.512

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.135

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.688

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.849

NRP_1Non-replicating persistence stage 1dosRassociated

0.787

Amp0.2mg/mL AmpicillincellWall

0.410

Cephalexin20-100 ug/mL CephalexincellWall

0.865

Cerulenin0.32-5 ug/mL CerulenincellWall

0.663

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.605

EMB10-20 ug/mL EthambutolcellWall

0.811

Eta12-40 ug/mL EthionamidecellWall

0.527

INH0.2-0.4 ug/mL IsoniazidcellWall

0.847

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.652

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.280

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

BZA0.12 mg/mL BenzamidearomaticAmides

0.000

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.000

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.000

H2O24 mM hydrogen peroxideDNAdamaging

0.392

Levo10 ug/mL LevofloxacinDNAdamaging

0.000

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.219

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.849

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.000

UVUV-irradiationDNAdamaging

-1.111

ARP41-4 ug/mL Antitubercular compound ARP4?

1.250

Antimycin12.5-50 ug/mL Antimycin A?

0.622

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.400

PA_110-50 ug/mL Antitubercular compound PA-1?

0.226

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.883

PA8240.2-2 ug/mL PA-824?

-1.039

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.067

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.690

Verapamil50 uM Verapamil?

0.823

mercaptoethanol2 mM 2-Mercaptoethanol?

0.784

methoxatin10-20 ug/mL Methoxatin?