from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1960c/parD1

LFCtreatmentdescriptionclass of inhibitor

1.643

Amikacinug/mL Amikacintranslation

1.622

Cap5-10ug/mL Capreomycintranslation

2.657

Rox10-50 ug/mL Roxithromycintranslation

1.022

SM2-5 ug/mL Streptomycintranslation

2.868

Tet5-10 ug/mL Tetracyclinetranslation

0.062

Rif0.2-5ug/mL Rifampicintranscription

0.238

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.527

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.688

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.668

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.299

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.564

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.129

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.195

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.551

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.377

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.669

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.131

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.881

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.243

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.482

KCN5-20 ug/mL Potassium cyaniderespiration

-0.038

NaN30.2-2 mM Sodium aziderespiration

1.428

Nigericin50 uM Nigericinrespiration

-0.158

TRC10-150 ug/mL Triclosanrespiration

0.148

TRZ10-25 ug/mL Thioridazinerespiration

2.388

Valinomycin0.5-10 uM Valinomycinrespiration

-0.117

ZnSO42 mM ZnSO4respiration

0.193

menadione6-10 ug/mL Menadionerespiration

-0.184

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.360

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.196

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.369

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.702

NRP_1Non-replicating persistence stage 1dosRassociated

0.293

Amp0.2mg/mL AmpicillincellWall

-0.097

Cephalexin20-100 ug/mL CephalexincellWall

0.125

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.097

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.033

EMB10-20 ug/mL EthambutolcellWall

0.428

Eta12-40 ug/mL EthionamidecellWall

0.838

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.064

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.561

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.133

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.100

BZA0.12 mg/mL BenzamidearomaticAmides

-0.039

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.037

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.296

H2O24 mM hydrogen peroxideDNAdamaging

0.104

Levo10 ug/mL LevofloxacinDNAdamaging

0.073

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.672

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.007

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.409

UVUV-irradiationDNAdamaging

-0.979

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.937

Antimycin12.5-50 ug/mL Antimycin A?

0.077

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.767

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.807

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.400

PA8240.2-2 ug/mL PA-824?

-0.592

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.502

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.479

Verapamil50 uM Verapamil?

0.770

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.586

methoxatin10-20 ug/mL Methoxatin?