from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1951c/-

LFCtreatmentdescriptionclass of inhibitor

1.283

Amikacinug/mL Amikacintranslation

1.119

Cap5-10ug/mL Capreomycintranslation

1.926

Rox10-50 ug/mL Roxithromycintranslation

0.412

SM2-5 ug/mL Streptomycintranslation

1.610

Tet5-10 ug/mL Tetracyclinetranslation

0.000

Rif0.2-5ug/mL Rifampicintranscription

0.091

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.934

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.118

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.284

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.544

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.026

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.235

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.041

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.052

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.065

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.476

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.086

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.410

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.613

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.116

KCN5-20 ug/mL Potassium cyaniderespiration

-0.128

NaN30.2-2 mM Sodium aziderespiration

0.523

Nigericin50 uM Nigericinrespiration

-0.464

TRC10-150 ug/mL Triclosanrespiration

0.685

TRZ10-25 ug/mL Thioridazinerespiration

0.752

Valinomycin0.5-10 uM Valinomycinrespiration

0.902

ZnSO42 mM ZnSO4respiration

1.010

menadione6-10 ug/mL Menadionerespiration

-0.028

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.422

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.241

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.106

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.494

NRP_1Non-replicating persistence stage 1dosRassociated

-0.269

Amp0.2mg/mL AmpicillincellWall

-0.174

Cephalexin20-100 ug/mL CephalexincellWall

0.328

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.355

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.265

EMB10-20 ug/mL EthambutolcellWall

0.514

Eta12-40 ug/mL EthionamidecellWall

0.908

INH0.2-0.4 ug/mL IsoniazidcellWall

0.456

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.088

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.541

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.352

BZA0.12 mg/mL BenzamidearomaticAmides

-0.140

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.109

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.208

H2O24 mM hydrogen peroxideDNAdamaging

0.274

Levo10 ug/mL LevofloxacinDNAdamaging

-0.428

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.994

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.389

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.208

UVUV-irradiationDNAdamaging

0.815

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.203

Antimycin12.5-50 ug/mL Antimycin A?

-0.400

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.425

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.671

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.067

PA8240.2-2 ug/mL PA-824?

-1.193

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.507

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.092

Verapamil50 uM Verapamil?

-0.315

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.337

methoxatin10-20 ug/mL Methoxatin?