from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1944c/-

LFCtreatmentdescriptionclass of inhibitor

1.507

Amikacinug/mL Amikacintranslation

1.419

Cap5-10ug/mL Capreomycintranslation

0.229

Rox10-50 ug/mL Roxithromycintranslation

0.741

SM2-5 ug/mL Streptomycintranslation

2.063

Tet5-10 ug/mL Tetracyclinetranslation

0.568

Rif0.2-5ug/mL Rifampicintranscription

0.962

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.855

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.340

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.272

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.992

Clofazimine10-13 ug/mL Clofaziminerespiration

0.052

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.636

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.036

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.328

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.006

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.308

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.731

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.709

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.702

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.917

KCN5-20 ug/mL Potassium cyaniderespiration

0.246

NaN30.2-2 mM Sodium aziderespiration

-0.006

Nigericin50 uM Nigericinrespiration

-0.279

TRC10-150 ug/mL Triclosanrespiration

-0.678

TRZ10-25 ug/mL Thioridazinerespiration

0.460

Valinomycin0.5-10 uM Valinomycinrespiration

0.796

ZnSO42 mM ZnSO4respiration

0.752

menadione6-10 ug/mL Menadionerespiration

0.439

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.142

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.433

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.018

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.226

NRP_1Non-replicating persistence stage 1dosRassociated

0.958

Amp0.2mg/mL AmpicillincellWall

0.435

Cephalexin20-100 ug/mL CephalexincellWall

0.599

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.201

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.435

EMB10-20 ug/mL EthambutolcellWall

0.223

Eta12-40 ug/mL EthionamidecellWall

-0.072

INH0.2-0.4 ug/mL IsoniazidcellWall

0.051

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.471

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.317

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

BZA0.12 mg/mL BenzamidearomaticAmides

0.000

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.000

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.000

H2O24 mM hydrogen peroxideDNAdamaging

0.361

Levo10 ug/mL LevofloxacinDNAdamaging

0.000

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.022

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.180

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.000

UVUV-irradiationDNAdamaging

0.639

ARP41-4 ug/mL Antitubercular compound ARP4?

0.413

Antimycin12.5-50 ug/mL Antimycin A?

0.363

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.725

PA_110-50 ug/mL Antitubercular compound PA-1?

0.657

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.678

PA8240.2-2 ug/mL PA-824?

-0.140

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.164

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.308

Verapamil50 uM Verapamil?

1.071

mercaptoethanol2 mM 2-Mercaptoethanol?

0.042

methoxatin10-20 ug/mL Methoxatin?