from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1937/-

LFCtreatmentdescriptionclass of inhibitor

-0.233

Amikacinug/mL Amikacintranslation

-1.200

Cap5-10ug/mL Capreomycintranslation

-0.795

Rox10-50 ug/mL Roxithromycintranslation

-0.464

SM2-5 ug/mL Streptomycintranslation

-2.332

Tet5-10 ug/mL Tetracyclinetranslation

0.513

Rif0.2-5ug/mL Rifampicintranscription

0.421

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.717

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.290

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.570

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.242

Clofazimine10-13 ug/mL Clofaziminerespiration

0.060

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

3.581

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.218

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.449

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.392

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.613

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.018

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.085

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.430

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.780

KCN5-20 ug/mL Potassium cyaniderespiration

1.668

NaN30.2-2 mM Sodium aziderespiration

-0.080

Nigericin50 uM Nigericinrespiration

0.862

TRC10-150 ug/mL Triclosanrespiration

-0.294

TRZ10-25 ug/mL Thioridazinerespiration

1.040

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.337

menadione6-10 ug/mL Menadionerespiration

0.025

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.163

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.255

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.209

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.300

NRP_1Non-replicating persistence stage 1dosRassociated

-0.423

Amp0.2mg/mL AmpicillincellWall

-0.251

Cephalexin20-100 ug/mL CephalexincellWall

-0.099

Cerulenin0.32-5 ug/mL CerulenincellWall

0.020

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.523

EMB10-20 ug/mL EthambutolcellWall

-0.636

Eta12-40 ug/mL EthionamidecellWall

-0.675

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.114

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.716

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.256

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.097

BZA0.12 mg/mL BenzamidearomaticAmides

-0.178

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.235

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.072

H2O24 mM hydrogen peroxideDNAdamaging

-0.535

Levo10 ug/mL LevofloxacinDNAdamaging

-0.642

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.477

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.530

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.299

UVUV-irradiationDNAdamaging

-0.376

ARP41-4 ug/mL Antitubercular compound ARP4?

0.276

Antimycin12.5-50 ug/mL Antimycin A?

-0.480

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.316

PA_110-50 ug/mL Antitubercular compound PA-1?

0.079

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.667

PA8240.2-2 ug/mL PA-824?

-0.288

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.059

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.147

Verapamil50 uM Verapamil?

0.192

mercaptoethanol2 mM 2-Mercaptoethanol?

0.053

methoxatin10-20 ug/mL Methoxatin?