from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1934c/fadE17

LFCtreatmentdescriptionclass of inhibitor

-0.438

Amikacinug/mL Amikacintranslation

0.225

Cap5-10ug/mL Capreomycintranslation

-0.278

Rox10-50 ug/mL Roxithromycintranslation

-0.586

SM2-5 ug/mL Streptomycintranslation

1.801

Tet5-10 ug/mL Tetracyclinetranslation

0.700

Rif0.2-5ug/mL Rifampicintranscription

0.410

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.150

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.659

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.467

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.636

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.247

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.411

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.702

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.464

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.876

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.515

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.838

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.296

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.622

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.006

Nigericin50 uM Nigericinrespiration

0.223

TRC10-150 ug/mL Triclosanrespiration

1.442

TRZ10-25 ug/mL Thioridazinerespiration

0.135

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.096

menadione6-10 ug/mL Menadionerespiration

-0.393

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.372

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.038

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.448

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.418

NRP_1Non-replicating persistence stage 1dosRassociated

-0.220

Amp0.2mg/mL AmpicillincellWall

0.189

Cephalexin20-100 ug/mL CephalexincellWall

1.440

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.362

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.508

EMB10-20 ug/mL EthambutolcellWall

0.137

Eta12-40 ug/mL EthionamidecellWall

-0.038

INH0.2-0.4 ug/mL IsoniazidcellWall

0.082

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.106

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.441

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.418

BZA0.12 mg/mL BenzamidearomaticAmides

-0.021

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.060

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.061

H2O24 mM hydrogen peroxideDNAdamaging

-0.311

Levo10 ug/mL LevofloxacinDNAdamaging

-0.213

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.127

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.139

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.388

UVUV-irradiationDNAdamaging

-0.257

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.824

Antimycin12.5-50 ug/mL Antimycin A?

-0.526

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.347

PA_110-50 ug/mL Antitubercular compound PA-1?

0.964

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.208

PA8240.2-2 ug/mL PA-824?

-0.307

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.802

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.641

Verapamil50 uM Verapamil?

-0.142

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.000

methoxatin10-20 ug/mL Methoxatin?