from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1930c/-

LFCtreatmentdescriptionclass of inhibitor

-0.178

Amikacinug/mL Amikacintranslation

-0.379

Cap5-10ug/mL Capreomycintranslation

0.611

Rox10-50 ug/mL Roxithromycintranslation

0.659

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.919

Rif0.2-5ug/mL Rifampicintranscription

-1.026

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.264

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.083

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.246

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.717

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.721

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.783

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.302

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.509

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.047

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.327

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.046

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.929

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.319

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.023

Nigericin50 uM Nigericinrespiration

0.085

TRC10-150 ug/mL Triclosanrespiration

0.386

TRZ10-25 ug/mL Thioridazinerespiration

-1.401

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.448

menadione6-10 ug/mL Menadionerespiration

-0.158

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.487

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.301

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.696

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.119

NRP_1Non-replicating persistence stage 1dosRassociated

-0.006

Amp0.2mg/mL AmpicillincellWall

0.107

Cephalexin20-100 ug/mL CephalexincellWall

0.889

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.220

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.197

EMB10-20 ug/mL EthambutolcellWall

0.439

Eta12-40 ug/mL EthionamidecellWall

0.367

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.296

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.423

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.514

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.606

BZA0.12 mg/mL BenzamidearomaticAmides

0.116

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.730

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.432

H2O24 mM hydrogen peroxideDNAdamaging

-0.071

Levo10 ug/mL LevofloxacinDNAdamaging

0.038

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.658

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.158

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.288

UVUV-irradiationDNAdamaging

-1.711

ARP41-4 ug/mL Antitubercular compound ARP4?

0.056

Antimycin12.5-50 ug/mL Antimycin A?

0.649

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.122

PA_110-50 ug/mL Antitubercular compound PA-1?

0.158

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.194

PA8240.2-2 ug/mL PA-824?

0.096

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.292

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.995

Verapamil50 uM Verapamil?

0.061

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.038

methoxatin10-20 ug/mL Methoxatin?