from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1929c/-

LFCtreatmentdescriptionclass of inhibitor

1.011

Amikacinug/mL Amikacintranslation

0.457

Cap5-10ug/mL Capreomycintranslation

1.174

Rox10-50 ug/mL Roxithromycintranslation

-0.056

SM2-5 ug/mL Streptomycintranslation

1.169

Tet5-10 ug/mL Tetracyclinetranslation

-0.050

Rif0.2-5ug/mL Rifampicintranscription

-0.265

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.227

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.323

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.392

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.546

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.240

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.488

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.438

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.042

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.513

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.683

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.183

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.075

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.073

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.394

KCN5-20 ug/mL Potassium cyaniderespiration

-0.332

NaN30.2-2 mM Sodium aziderespiration

-0.153

Nigericin50 uM Nigericinrespiration

-0.303

TRC10-150 ug/mL Triclosanrespiration

0.297

TRZ10-25 ug/mL Thioridazinerespiration

4.686

Valinomycin0.5-10 uM Valinomycinrespiration

-0.258

ZnSO42 mM ZnSO4respiration

0.279

menadione6-10 ug/mL Menadionerespiration

-0.665

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.175

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.193

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.538

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.083

NRP_1Non-replicating persistence stage 1dosRassociated

-0.551

Amp0.2mg/mL AmpicillincellWall

-0.322

Cephalexin20-100 ug/mL CephalexincellWall

-0.409

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.552

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.454

EMB10-20 ug/mL EthambutolcellWall

-0.388

Eta12-40 ug/mL EthionamidecellWall

-0.184

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.390

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.322

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.468

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

BZA0.12 mg/mL BenzamidearomaticAmides

0.000

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.000

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.000

H2O24 mM hydrogen peroxideDNAdamaging

-0.240

Levo10 ug/mL LevofloxacinDNAdamaging

0.000

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.103

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.122

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.000

UVUV-irradiationDNAdamaging

-0.108

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.521

Antimycin12.5-50 ug/mL Antimycin A?

-0.399

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.503

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.617

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.706

PA8240.2-2 ug/mL PA-824?

1.374

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.623

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.525

Verapamil50 uM Verapamil?

-0.045

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.614

methoxatin10-20 ug/mL Methoxatin?