from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1928c/-

LFCtreatmentdescriptionclass of inhibitor

-0.143

Amikacinug/mL Amikacintranslation

0.260

Cap5-10ug/mL Capreomycintranslation

0.547

Rox10-50 ug/mL Roxithromycintranslation

-0.317

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

1.175

Rif0.2-5ug/mL Rifampicintranscription

-0.816

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.111

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.638

CPZ10-50 ug/mL Chlorpromazinerespiration

0.069

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.106

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.009

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.334

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.425

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.197

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.304

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.211

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.456

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.069

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.768

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.002

Nigericin50 uM Nigericinrespiration

0.049

TRC10-150 ug/mL Triclosanrespiration

-1.036

TRZ10-25 ug/mL Thioridazinerespiration

-1.089

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.171

menadione6-10 ug/mL Menadionerespiration

-0.412

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.114

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.182

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.339

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.067

NRP_1Non-replicating persistence stage 1dosRassociated

1.158

Amp0.2mg/mL AmpicillincellWall

0.083

Cephalexin20-100 ug/mL CephalexincellWall

0.232

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.017

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.379

EMB10-20 ug/mL EthambutolcellWall

-0.184

Eta12-40 ug/mL EthionamidecellWall

-0.118

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.012

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.330

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.128

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.329

BZA0.12 mg/mL BenzamidearomaticAmides

-0.089

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.333

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.799

H2O24 mM hydrogen peroxideDNAdamaging

-0.061

Levo10 ug/mL LevofloxacinDNAdamaging

0.082

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.222

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.002

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.117

UVUV-irradiationDNAdamaging

-0.520

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.230

Antimycin12.5-50 ug/mL Antimycin A?

-0.753

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.337

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.006

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.365

PA8240.2-2 ug/mL PA-824?

-0.056

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.123

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.830

Verapamil50 uM Verapamil?

-1.232

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.612

methoxatin10-20 ug/mL Methoxatin?