from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1926c/mpt63

LFCtreatmentdescriptionclass of inhibitor

1.536

Amikacinug/mL Amikacintranslation

1.783

Cap5-10ug/mL Capreomycintranslation

2.136

Rox10-50 ug/mL Roxithromycintranslation

0.329

SM2-5 ug/mL Streptomycintranslation

1.237

Tet5-10 ug/mL Tetracyclinetranslation

-0.073

Rif0.2-5ug/mL Rifampicintranscription

0.393

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.741

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.589

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.943

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.377

Clofazimine10-13 ug/mL Clofaziminerespiration

0.149

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.775

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.705

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.831

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.026

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.179

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.863

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.187

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.249

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.978

KCN5-20 ug/mL Potassium cyaniderespiration

0.158

NaN30.2-2 mM Sodium aziderespiration

0.161

Nigericin50 uM Nigericinrespiration

0.263

TRC10-150 ug/mL Triclosanrespiration

-0.027

TRZ10-25 ug/mL Thioridazinerespiration

0.051

Valinomycin0.5-10 uM Valinomycinrespiration

-1.248

ZnSO42 mM ZnSO4respiration

-0.517

menadione6-10 ug/mL Menadionerespiration

-0.438

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.310

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.351

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.088

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.011

NRP_1Non-replicating persistence stage 1dosRassociated

0.022

Amp0.2mg/mL AmpicillincellWall

-0.300

Cephalexin20-100 ug/mL CephalexincellWall

-0.310

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.499

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.388

EMB10-20 ug/mL EthambutolcellWall

-0.004

Eta12-40 ug/mL EthionamidecellWall

-0.252

INH0.2-0.4 ug/mL IsoniazidcellWall

0.094

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.153

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.419

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.816

BZA0.12 mg/mL BenzamidearomaticAmides

0.506

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.480

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.043

H2O24 mM hydrogen peroxideDNAdamaging

0.494

Levo10 ug/mL LevofloxacinDNAdamaging

0.138

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.060

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.711

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.248

UVUV-irradiationDNAdamaging

-1.122

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.027

Antimycin12.5-50 ug/mL Antimycin A?

-0.449

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.361

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.518

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.537

PA8240.2-2 ug/mL PA-824?

-1.133

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.740

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.358

Verapamil50 uM Verapamil?

0.651

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.672

methoxatin10-20 ug/mL Methoxatin?