from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1924c/-

LFCtreatmentdescriptionclass of inhibitor

1.024

Amikacinug/mL Amikacintranslation

3.142

Cap5-10ug/mL Capreomycintranslation

2.702

Rox10-50 ug/mL Roxithromycintranslation

-0.004

SM2-5 ug/mL Streptomycintranslation

1.973

Tet5-10 ug/mL Tetracyclinetranslation

0.419

Rif0.2-5ug/mL Rifampicintranscription

-0.331

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.132

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.362

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.358

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.080

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.119

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.507

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.860

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.352

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.713

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.958

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.345

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.437

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.648

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.207

KCN5-20 ug/mL Potassium cyaniderespiration

0.148

NaN30.2-2 mM Sodium aziderespiration

-0.217

Nigericin50 uM Nigericinrespiration

-0.042

TRC10-150 ug/mL Triclosanrespiration

-0.162

TRZ10-25 ug/mL Thioridazinerespiration

-0.307

Valinomycin0.5-10 uM Valinomycinrespiration

1.676

ZnSO42 mM ZnSO4respiration

-0.221

menadione6-10 ug/mL Menadionerespiration

-0.313

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.169

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.093

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.161

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.587

NRP_1Non-replicating persistence stage 1dosRassociated

-0.195

Amp0.2mg/mL AmpicillincellWall

-0.170

Cephalexin20-100 ug/mL CephalexincellWall

0.751

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.449

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.211

EMB10-20 ug/mL EthambutolcellWall

0.478

Eta12-40 ug/mL EthionamidecellWall

0.654

INH0.2-0.4 ug/mL IsoniazidcellWall

0.432

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.396

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.165

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.179

BZA0.12 mg/mL BenzamidearomaticAmides

0.218

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.157

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.153

H2O24 mM hydrogen peroxideDNAdamaging

-0.015

Levo10 ug/mL LevofloxacinDNAdamaging

-0.466

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.069

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.383

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.825

UVUV-irradiationDNAdamaging

-0.059

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.080

Antimycin12.5-50 ug/mL Antimycin A?

0.102

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.281

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.069

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.815

PA8240.2-2 ug/mL PA-824?

0.219

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.516

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.563

Verapamil50 uM Verapamil?

-0.349

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.208

methoxatin10-20 ug/mL Methoxatin?