from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1914c/-

LFCtreatmentdescriptionclass of inhibitor

-0.770

Amikacinug/mL Amikacintranslation

1.069

Cap5-10ug/mL Capreomycintranslation

0.613

Rox10-50 ug/mL Roxithromycintranslation

-0.060

SM2-5 ug/mL Streptomycintranslation

-0.984

Tet5-10 ug/mL Tetracyclinetranslation

-2.274

Rif0.2-5ug/mL Rifampicintranscription

-0.045

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

3.193

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.577

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.676

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.367

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.609

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.000

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.000

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

1.370

Nigericin50 uM Nigericinrespiration

-0.649

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

1.149

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.000

menadione6-10 ug/mL Menadionerespiration

0.494

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.270

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.092

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.749

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.692

NRP_1Non-replicating persistence stage 1dosRassociated

-0.521

Amp0.2mg/mL AmpicillincellWall

0.006

Cephalexin20-100 ug/mL CephalexincellWall

0.459

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.300

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-1.189

EMB10-20 ug/mL EthambutolcellWall

-0.393

Eta12-40 ug/mL EthionamidecellWall

-0.174

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.303

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.015

BZA0.12 mg/mL BenzamidearomaticAmides

-0.055

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.114

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.677

H2O24 mM hydrogen peroxideDNAdamaging

1.628

Levo10 ug/mL LevofloxacinDNAdamaging

-0.004

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.349

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.358

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.520

Antimycin12.5-50 ug/mL Antimycin A?

2.318

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.616

PA_110-50 ug/mL Antitubercular compound PA-1?

0.062

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.160

PA8240.2-2 ug/mL PA-824?

0.500

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.566

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

2.186

mercaptoethanol2 mM 2-Mercaptoethanol?

0.000

methoxatin10-20 ug/mL Methoxatin?