from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1909c/furA

LFCtreatmentdescriptionclass of inhibitor

1.413

Amikacinug/mL Amikacintranslation

1.194

Cap5-10ug/mL Capreomycintranslation

2.070

Rox10-50 ug/mL Roxithromycintranslation

1.033

SM2-5 ug/mL Streptomycintranslation

1.229

Tet5-10 ug/mL Tetracyclinetranslation

-0.716

Rif0.2-5ug/mL Rifampicintranscription

-0.494

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.220

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.763

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.220

CPZ10-50 ug/mL Chlorpromazinerespiration

2.482

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.509

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.484

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.491

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.480

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.463

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.731

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.181

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.390

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

2.333

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.729

KCN5-20 ug/mL Potassium cyaniderespiration

0.474

NaN30.2-2 mM Sodium aziderespiration

0.320

Nigericin50 uM Nigericinrespiration

0.887

TRC10-150 ug/mL Triclosanrespiration

0.720

TRZ10-25 ug/mL Thioridazinerespiration

0.284

Valinomycin0.5-10 uM Valinomycinrespiration

-0.240

ZnSO42 mM ZnSO4respiration

2.112

menadione6-10 ug/mL Menadionerespiration

-1.484

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.852

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.951

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.411

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.621

NRP_1Non-replicating persistence stage 1dosRassociated

-0.407

Amp0.2mg/mL AmpicillincellWall

-0.596

Cephalexin20-100 ug/mL CephalexincellWall

-0.611

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.461

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.754

EMB10-20 ug/mL EthambutolcellWall

-0.520

Eta12-40 ug/mL EthionamidecellWall

-0.829

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.267

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.324

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.736

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.114

BZA0.12 mg/mL BenzamidearomaticAmides

-0.024

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.547

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.142

H2O24 mM hydrogen peroxideDNAdamaging

-0.367

Levo10 ug/mL LevofloxacinDNAdamaging

-0.520

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.069

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.411

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.851

UVUV-irradiationDNAdamaging

2.479

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.735

Antimycin12.5-50 ug/mL Antimycin A?

-0.572

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.214

PA_110-50 ug/mL Antitubercular compound PA-1?

0.284

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.276

PA8240.2-2 ug/mL PA-824?

-0.647

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.861

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.603

Verapamil50 uM Verapamil?

0.014

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.397

methoxatin10-20 ug/mL Methoxatin?