from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1907c/-

LFCtreatmentdescriptionclass of inhibitor

-0.170

Amikacinug/mL Amikacintranslation

-0.498

Cap5-10ug/mL Capreomycintranslation

-0.311

Rox10-50 ug/mL Roxithromycintranslation

0.299

SM2-5 ug/mL Streptomycintranslation

-0.791

Tet5-10 ug/mL Tetracyclinetranslation

-0.770

Rif0.2-5ug/mL Rifampicintranscription

-0.434

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.712

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.195

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.778

CPZ10-50 ug/mL Chlorpromazinerespiration

1.940

Clofazimine10-13 ug/mL Clofaziminerespiration

-1.010

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.099

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.399

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.665

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.013

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.483

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.033

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.259

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.911

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

3.343

KCN5-20 ug/mL Potassium cyaniderespiration

-1.076

NaN30.2-2 mM Sodium aziderespiration

0.157

Nigericin50 uM Nigericinrespiration

-0.145

TRC10-150 ug/mL Triclosanrespiration

-1.230

TRZ10-25 ug/mL Thioridazinerespiration

0.246

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.943

menadione6-10 ug/mL Menadionerespiration

-0.885

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.634

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.870

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.553

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.539

NRP_1Non-replicating persistence stage 1dosRassociated

-0.221

Amp0.2mg/mL AmpicillincellWall

-0.693

Cephalexin20-100 ug/mL CephalexincellWall

-0.695

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.673

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.527

EMB10-20 ug/mL EthambutolcellWall

-0.116

Eta12-40 ug/mL EthionamidecellWall

0.034

INH0.2-0.4 ug/mL IsoniazidcellWall

0.019

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.355

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.542

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.632

BZA0.12 mg/mL BenzamidearomaticAmides

0.648

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.295

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.037

H2O24 mM hydrogen peroxideDNAdamaging

1.415

Levo10 ug/mL LevofloxacinDNAdamaging

0.294

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.215

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.651

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.111

UVUV-irradiationDNAdamaging

0.370

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.411

Antimycin12.5-50 ug/mL Antimycin A?

-0.403

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.574

PA_110-50 ug/mL Antitubercular compound PA-1?

0.179

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.537

PA8240.2-2 ug/mL PA-824?

-0.048

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.269

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.339

Verapamil50 uM Verapamil?

0.640

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.197

methoxatin10-20 ug/mL Methoxatin?