from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1885c/-

LFCtreatmentdescriptionclass of inhibitor

0.872

Amikacinug/mL Amikacintranslation

1.134

Cap5-10ug/mL Capreomycintranslation

0.203

Rox10-50 ug/mL Roxithromycintranslation

1.569

SM2-5 ug/mL Streptomycintranslation

0.849

Tet5-10 ug/mL Tetracyclinetranslation

0.207

Rif0.2-5ug/mL Rifampicintranscription

0.257

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.234

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.153

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.731

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.000

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.458

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.000

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.729

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.011

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.658

Nigericin50 uM Nigericinrespiration

-0.259

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

1.255

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

1.111

menadione6-10 ug/mL Menadionerespiration

0.334

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.217

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.385

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.000

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.325

NRP_1Non-replicating persistence stage 1dosRassociated

0.539

Amp0.2mg/mL AmpicillincellWall

-0.397

Cephalexin20-100 ug/mL CephalexincellWall

-1.210

Cerulenin0.32-5 ug/mL CerulenincellWall

0.685

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.132

EMB10-20 ug/mL EthambutolcellWall

-0.923

Eta12-40 ug/mL EthionamidecellWall

-1.278

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.966

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.137

BZA0.12 mg/mL BenzamidearomaticAmides

-0.235

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.259

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.165

H2O24 mM hydrogen peroxideDNAdamaging

-0.034

Levo10 ug/mL LevofloxacinDNAdamaging

-0.039

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.340

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.176

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.231

Antimycin12.5-50 ug/mL Antimycin A?

1.596

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.116

PA_110-50 ug/mL Antitubercular compound PA-1?

0.123

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.089

PA8240.2-2 ug/mL PA-824?

-1.903

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.534

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.957

Verapamil50 uM Verapamil?

1.331

mercaptoethanol2 mM 2-Mercaptoethanol?

1.282

methoxatin10-20 ug/mL Methoxatin?