from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1884c/rpfC

LFCtreatmentdescriptionclass of inhibitor

0.607

Amikacinug/mL Amikacintranslation

1.137

Cap5-10ug/mL Capreomycintranslation

2.032

Rox10-50 ug/mL Roxithromycintranslation

-0.157

SM2-5 ug/mL Streptomycintranslation

0.353

Tet5-10 ug/mL Tetracyclinetranslation

-0.612

Rif0.2-5ug/mL Rifampicintranscription

0.716

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.505

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.374

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.468

CPZ10-50 ug/mL Chlorpromazinerespiration

0.172

Clofazimine10-13 ug/mL Clofaziminerespiration

0.728

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.524

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.299

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.352

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.746

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.300

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.083

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.695

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.822

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.582

KCN5-20 ug/mL Potassium cyaniderespiration

-1.356

NaN30.2-2 mM Sodium aziderespiration

1.485

Nigericin50 uM Nigericinrespiration

-0.399

TRC10-150 ug/mL Triclosanrespiration

-0.707

TRZ10-25 ug/mL Thioridazinerespiration

0.411

Valinomycin0.5-10 uM Valinomycinrespiration

0.084

ZnSO42 mM ZnSO4respiration

-1.818

menadione6-10 ug/mL Menadionerespiration

-1.055

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.683

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.334

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.833

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-2.438

NRP_1Non-replicating persistence stage 1dosRassociated

0.131

Amp0.2mg/mL AmpicillincellWall

-0.575

Cephalexin20-100 ug/mL CephalexincellWall

0.057

Cerulenin0.32-5 ug/mL CerulenincellWall

0.728

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.167

EMB10-20 ug/mL EthambutolcellWall

-0.709

Eta12-40 ug/mL EthionamidecellWall

-0.441

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.804

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.259

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.983

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.280

BZA0.12 mg/mL BenzamidearomaticAmides

0.686

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.501

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.341

H2O24 mM hydrogen peroxideDNAdamaging

0.801

Levo10 ug/mL LevofloxacinDNAdamaging

0.102

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.280

Novobiocin10 ug/mL NovobiocinDNAdamaging

-1.468

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.234

UVUV-irradiationDNAdamaging

-0.765

ARP41-4 ug/mL Antitubercular compound ARP4?

0.774

Antimycin12.5-50 ug/mL Antimycin A?

0.479

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.461

PA_110-50 ug/mL Antitubercular compound PA-1?

0.776

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.841

PA8240.2-2 ug/mL PA-824?

-0.662

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.278

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.460

Verapamil50 uM Verapamil?

0.964

mercaptoethanol2 mM 2-Mercaptoethanol?

0.648

methoxatin10-20 ug/mL Methoxatin?