from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1883c/-

LFCtreatmentdescriptionclass of inhibitor

1.301

Amikacinug/mL Amikacintranslation

0.803

Cap5-10ug/mL Capreomycintranslation

2.569

Rox10-50 ug/mL Roxithromycintranslation

0.617

SM2-5 ug/mL Streptomycintranslation

0.943

Tet5-10 ug/mL Tetracyclinetranslation

-1.011

Rif0.2-5ug/mL Rifampicintranscription

-0.097

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.919

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.416

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-1.344

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.344

Clofazimine10-13 ug/mL Clofaziminerespiration

0.305

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.438

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.548

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.980

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.260

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.221

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-2.271

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.469

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.416

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.835

KCN5-20 ug/mL Potassium cyaniderespiration

-0.572

NaN30.2-2 mM Sodium aziderespiration

2.377

Nigericin50 uM Nigericinrespiration

-0.167

TRC10-150 ug/mL Triclosanrespiration

-0.731

TRZ10-25 ug/mL Thioridazinerespiration

0.936

Valinomycin0.5-10 uM Valinomycinrespiration

0.155

ZnSO42 mM ZnSO4respiration

-1.337

menadione6-10 ug/mL Menadionerespiration

-0.563

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.492

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.021

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.862

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.735

NRP_1Non-replicating persistence stage 1dosRassociated

0.329

Amp0.2mg/mL AmpicillincellWall

-0.084

Cephalexin20-100 ug/mL CephalexincellWall

-0.033

Cerulenin0.32-5 ug/mL CerulenincellWall

0.555

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.029

EMB10-20 ug/mL EthambutolcellWall

0.041

Eta12-40 ug/mL EthionamidecellWall

0.515

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.309

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.183

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.151

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.346

BZA0.12 mg/mL BenzamidearomaticAmides

0.139

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.584

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.639

H2O24 mM hydrogen peroxideDNAdamaging

0.469

Levo10 ug/mL LevofloxacinDNAdamaging

0.244

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.045

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.325

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.119

UVUV-irradiationDNAdamaging

-1.846

ARP41-4 ug/mL Antitubercular compound ARP4?

0.517

Antimycin12.5-50 ug/mL Antimycin A?

0.695

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.324

PA_110-50 ug/mL Antitubercular compound PA-1?

0.580

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.001

PA8240.2-2 ug/mL PA-824?

-0.618

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.105

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.337

Verapamil50 uM Verapamil?

0.849

mercaptoethanol2 mM 2-Mercaptoethanol?

0.699

methoxatin10-20 ug/mL Methoxatin?