from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1809/PPE33

LFCtreatmentdescriptionclass of inhibitor

-0.559

Amikacinug/mL Amikacintranslation

-0.554

Cap5-10ug/mL Capreomycintranslation

1.664

Rox10-50 ug/mL Roxithromycintranslation

0.140

SM2-5 ug/mL Streptomycintranslation

-1.438

Tet5-10 ug/mL Tetracyclinetranslation

-1.300

Rif0.2-5ug/mL Rifampicintranscription

-0.535

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.607

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.951

CPZ10-50 ug/mL Chlorpromazinerespiration

0.629

Clofazimine10-13 ug/mL Clofaziminerespiration

0.781

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.881

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.980

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.993

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.137

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.910

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.609

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.048

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.566

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.639

Nigericin50 uM Nigericinrespiration

-0.300

TRC10-150 ug/mL Triclosanrespiration

0.769

TRZ10-25 ug/mL Thioridazinerespiration

-0.764

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.861

menadione6-10 ug/mL Menadionerespiration

0.573

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.543

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.416

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.164

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.163

NRP_1Non-replicating persistence stage 1dosRassociated

0.153

Amp0.2mg/mL AmpicillincellWall

0.418

Cephalexin20-100 ug/mL CephalexincellWall

-0.071

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.512

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.008

EMB10-20 ug/mL EthambutolcellWall

-0.242

Eta12-40 ug/mL EthionamidecellWall

-0.244

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.567

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.547

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.193

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.404

BZA0.12 mg/mL BenzamidearomaticAmides

0.630

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.630

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.265

H2O24 mM hydrogen peroxideDNAdamaging

-0.857

Levo10 ug/mL LevofloxacinDNAdamaging

-0.433

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.502

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.328

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.411

UVUV-irradiationDNAdamaging

0.241

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.452

Antimycin12.5-50 ug/mL Antimycin A?

-1.565

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.514

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.343

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.051

PA8240.2-2 ug/mL PA-824?

-0.154

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.267

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.677

Verapamil50 uM Verapamil?

-1.655

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.383

methoxatin10-20 ug/mL Methoxatin?