from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1806/PE20

LFCtreatmentdescriptionclass of inhibitor

1.908

Amikacinug/mL Amikacintranslation

2.259

Cap5-10ug/mL Capreomycintranslation

2.700

Rox10-50 ug/mL Roxithromycintranslation

0.426

SM2-5 ug/mL Streptomycintranslation

0.848

Tet5-10 ug/mL Tetracyclinetranslation

-0.482

Rif0.2-5ug/mL Rifampicintranscription

-0.592

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.157

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.885

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.332

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.885

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.006

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.368

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.159

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.653

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.607

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.751

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.387

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.759

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.294

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.113

KCN5-20 ug/mL Potassium cyaniderespiration

-0.983

NaN30.2-2 mM Sodium aziderespiration

-0.997

Nigericin50 uM Nigericinrespiration

-0.572

TRC10-150 ug/mL Triclosanrespiration

1.399

TRZ10-25 ug/mL Thioridazinerespiration

1.984

Valinomycin0.5-10 uM Valinomycinrespiration

0.324

ZnSO42 mM ZnSO4respiration

0.183

menadione6-10 ug/mL Menadionerespiration

-0.143

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.575

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.590

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.665

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.158

NRP_1Non-replicating persistence stage 1dosRassociated

-0.474

Amp0.2mg/mL AmpicillincellWall

0.078

Cephalexin20-100 ug/mL CephalexincellWall

-0.401

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.251

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.724

EMB10-20 ug/mL EthambutolcellWall

-0.418

Eta12-40 ug/mL EthionamidecellWall

-0.724

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.678

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.710

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.047

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.443

BZA0.12 mg/mL BenzamidearomaticAmides

0.491

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.877

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.872

H2O24 mM hydrogen peroxideDNAdamaging

-0.474

Levo10 ug/mL LevofloxacinDNAdamaging

-0.447

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.836

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.409

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.500

UVUV-irradiationDNAdamaging

-0.911

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.825

Antimycin12.5-50 ug/mL Antimycin A?

-0.621

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.597

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.563

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.239

PA8240.2-2 ug/mL PA-824?

-1.030

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.577

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.593

Verapamil50 uM Verapamil?

-0.527

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.834

methoxatin10-20 ug/mL Methoxatin?