from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1804c/-

LFCtreatmentdescriptionclass of inhibitor

0.507

Amikacinug/mL Amikacintranslation

1.166

Cap5-10ug/mL Capreomycintranslation

1.699

Rox10-50 ug/mL Roxithromycintranslation

-0.175

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.369

Rif0.2-5ug/mL Rifampicintranscription

-0.184

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.860

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.269

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.046

CPZ10-50 ug/mL Chlorpromazinerespiration

1.038

Clofazimine10-13 ug/mL Clofaziminerespiration

0.806

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.779

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.252

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.367

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.174

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.900

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.179

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.362

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.198

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.378

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.297

Nigericin50 uM Nigericinrespiration

0.898

TRC10-150 ug/mL Triclosanrespiration

0.100

TRZ10-25 ug/mL Thioridazinerespiration

-1.416

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.213

menadione6-10 ug/mL Menadionerespiration

0.195

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.271

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.306

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.043

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.033

NRP_1Non-replicating persistence stage 1dosRassociated

-0.585

Amp0.2mg/mL AmpicillincellWall

0.381

Cephalexin20-100 ug/mL CephalexincellWall

1.254

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.573

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.456

EMB10-20 ug/mL EthambutolcellWall

-0.117

Eta12-40 ug/mL EthionamidecellWall

-0.463

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.134

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.608

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.483

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.059

BZA0.12 mg/mL BenzamidearomaticAmides

-0.184

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.560

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.040

H2O24 mM hydrogen peroxideDNAdamaging

0.119

Levo10 ug/mL LevofloxacinDNAdamaging

-0.436

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.429

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.224

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.562

UVUV-irradiationDNAdamaging

0.359

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.624

Antimycin12.5-50 ug/mL Antimycin A?

-1.037

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.040

PA_110-50 ug/mL Antitubercular compound PA-1?

0.052

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.420

PA8240.2-2 ug/mL PA-824?

0.040

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.974

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.384

Verapamil50 uM Verapamil?

-1.009

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.063

methoxatin10-20 ug/mL Methoxatin?