from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1801/PPE29

LFCtreatmentdescriptionclass of inhibitor

-0.144

Amikacinug/mL Amikacintranslation

1.023

Cap5-10ug/mL Capreomycintranslation

-0.662

Rox10-50 ug/mL Roxithromycintranslation

0.541

SM2-5 ug/mL Streptomycintranslation

0.450

Tet5-10 ug/mL Tetracyclinetranslation

-0.275

Rif0.2-5ug/mL Rifampicintranscription

0.636

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.496

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.540

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.255

CPZ10-50 ug/mL Chlorpromazinerespiration

0.982

Clofazimine10-13 ug/mL Clofaziminerespiration

0.848

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.956

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.001

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.073

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.656

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.509

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.526

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.342

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.213

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.037

Nigericin50 uM Nigericinrespiration

0.406

TRC10-150 ug/mL Triclosanrespiration

0.103

TRZ10-25 ug/mL Thioridazinerespiration

-1.032

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.756

menadione6-10 ug/mL Menadionerespiration

0.163

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.110

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.216

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.141

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.826

NRP_1Non-replicating persistence stage 1dosRassociated

0.363

Amp0.2mg/mL AmpicillincellWall

0.251

Cephalexin20-100 ug/mL CephalexincellWall

1.547

Cerulenin0.32-5 ug/mL CerulenincellWall

0.691

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.474

EMB10-20 ug/mL EthambutolcellWall

-1.115

Eta12-40 ug/mL EthionamidecellWall

-0.521

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.279

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.595

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.671

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.597

BZA0.12 mg/mL BenzamidearomaticAmides

-0.038

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.191

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.187

H2O24 mM hydrogen peroxideDNAdamaging

0.021

Levo10 ug/mL LevofloxacinDNAdamaging

-0.550

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.808

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.144

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.164

UVUV-irradiationDNAdamaging

-0.390

ARP41-4 ug/mL Antitubercular compound ARP4?

0.327

Antimycin12.5-50 ug/mL Antimycin A?

-0.829

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.953

PA_110-50 ug/mL Antitubercular compound PA-1?

0.847

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.634

PA8240.2-2 ug/mL PA-824?

1.038

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

1.004

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.917

Verapamil50 uM Verapamil?

-0.644

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.108

methoxatin10-20 ug/mL Methoxatin?