from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1797/eccE5

LFCtreatmentdescriptionclass of inhibitor

-1.518

Amikacinug/mL Amikacintranslation

-0.928

Cap5-10ug/mL Capreomycintranslation

-1.608

Rox10-50 ug/mL Roxithromycintranslation

-0.783

SM2-5 ug/mL Streptomycintranslation

-2.231

Tet5-10 ug/mL Tetracyclinetranslation

-0.719

Rif0.2-5ug/mL Rifampicintranscription

0.649

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.338

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.012

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.091

CPZ10-50 ug/mL Chlorpromazinerespiration

1.340

Clofazimine10-13 ug/mL Clofaziminerespiration

0.830

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.402

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.239

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.099

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.800

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.611

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.067

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.817

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.040

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.575

KCN5-20 ug/mL Potassium cyaniderespiration

0.056

NaN30.2-2 mM Sodium aziderespiration

0.278

Nigericin50 uM Nigericinrespiration

0.073

TRC10-150 ug/mL Triclosanrespiration

0.835

TRZ10-25 ug/mL Thioridazinerespiration

-0.472

Valinomycin0.5-10 uM Valinomycinrespiration

0.279

ZnSO42 mM ZnSO4respiration

-0.413

menadione6-10 ug/mL Menadionerespiration

0.886

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.286

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.804

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.120

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.260

NRP_1Non-replicating persistence stage 1dosRassociated

-0.495

Amp0.2mg/mL AmpicillincellWall

0.319

Cephalexin20-100 ug/mL CephalexincellWall

0.353

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.236

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.646

EMB10-20 ug/mL EthambutolcellWall

0.281

Eta12-40 ug/mL EthionamidecellWall

0.261

INH0.2-0.4 ug/mL IsoniazidcellWall

0.063

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.362

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.455

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.278

BZA0.12 mg/mL BenzamidearomaticAmides

-1.066

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.909

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.490

H2O24 mM hydrogen peroxideDNAdamaging

-0.249

Levo10 ug/mL LevofloxacinDNAdamaging

-0.843

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.291

Novobiocin10 ug/mL NovobiocinDNAdamaging

-1.093

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.483

UVUV-irradiationDNAdamaging

0.755

ARP41-4 ug/mL Antitubercular compound ARP4?

0.450

Antimycin12.5-50 ug/mL Antimycin A?

0.617

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.448

PA_110-50 ug/mL Antitubercular compound PA-1?

0.796

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.624

PA8240.2-2 ug/mL PA-824?

1.225

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

1.016

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.590

Verapamil50 uM Verapamil?

0.423

mercaptoethanol2 mM 2-Mercaptoethanol?

0.590

methoxatin10-20 ug/mL Methoxatin?