from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1794/-

LFCtreatmentdescriptionclass of inhibitor

-0.148

Amikacinug/mL Amikacintranslation

0.620

Cap5-10ug/mL Capreomycintranslation

0.137

Rox10-50 ug/mL Roxithromycintranslation

0.839

SM2-5 ug/mL Streptomycintranslation

0.415

Tet5-10 ug/mL Tetracyclinetranslation

-0.634

Rif0.2-5ug/mL Rifampicintranscription

-0.076

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.833

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.325

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.350

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.145

Clofazimine10-13 ug/mL Clofaziminerespiration

0.389

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.808

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.222

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.354

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.355

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.251

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.376

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.329

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.128

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.136

KCN5-20 ug/mL Potassium cyaniderespiration

-0.115

NaN30.2-2 mM Sodium aziderespiration

-0.551

Nigericin50 uM Nigericinrespiration

-0.782

TRC10-150 ug/mL Triclosanrespiration

-0.046

TRZ10-25 ug/mL Thioridazinerespiration

-0.512

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.310

menadione6-10 ug/mL Menadionerespiration

1.144

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.456

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.995

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.509

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.933

NRP_1Non-replicating persistence stage 1dosRassociated

1.031

Amp0.2mg/mL AmpicillincellWall

0.024

Cephalexin20-100 ug/mL CephalexincellWall

0.044

Cerulenin0.32-5 ug/mL CerulenincellWall

0.996

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.538

EMB10-20 ug/mL EthambutolcellWall

-0.016

Eta12-40 ug/mL EthionamidecellWall

-0.202

INH0.2-0.4 ug/mL IsoniazidcellWall

0.131

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.659

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.357

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.633

BZA0.12 mg/mL BenzamidearomaticAmides

-1.084

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-1.673

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.004

H2O24 mM hydrogen peroxideDNAdamaging

-0.410

Levo10 ug/mL LevofloxacinDNAdamaging

0.981

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.381

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.029

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.491

UVUV-irradiationDNAdamaging

-1.225

ARP41-4 ug/mL Antitubercular compound ARP4?

0.353

Antimycin12.5-50 ug/mL Antimycin A?

-0.352

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.599

PA_110-50 ug/mL Antitubercular compound PA-1?

0.716

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.321

PA8240.2-2 ug/mL PA-824?

-1.047

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.000

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.590

Verapamil50 uM Verapamil?

-0.261

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.557

methoxatin10-20 ug/mL Methoxatin?