from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1791/PE19

LFCtreatmentdescriptionclass of inhibitor

0.950

Amikacinug/mL Amikacintranslation

1.646

Cap5-10ug/mL Capreomycintranslation

0.603

Rox10-50 ug/mL Roxithromycintranslation

0.262

SM2-5 ug/mL Streptomycintranslation

0.444

Tet5-10 ug/mL Tetracyclinetranslation

-1.106

Rif0.2-5ug/mL Rifampicintranscription

-0.734

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.935

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.516

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.444

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.228

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.373

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.831

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.175

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.095

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.976

KCN5-20 ug/mL Potassium cyaniderespiration

1.509

NaN30.2-2 mM Sodium aziderespiration

0.744

Nigericin50 uM Nigericinrespiration

-0.834

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.462

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.326

menadione6-10 ug/mL Menadionerespiration

0.696

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.350

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.059

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.811

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.853

NRP_1Non-replicating persistence stage 1dosRassociated

0.663

Amp0.2mg/mL AmpicillincellWall

0.568

Cephalexin20-100 ug/mL CephalexincellWall

0.281

Cerulenin0.32-5 ug/mL CerulenincellWall

0.978

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.640

EMB10-20 ug/mL EthambutolcellWall

0.111

Eta12-40 ug/mL EthionamidecellWall

-0.040

INH0.2-0.4 ug/mL IsoniazidcellWall

0.080

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.515

BZA0.12 mg/mL BenzamidearomaticAmides

-1.199

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-1.553

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.203

H2O24 mM hydrogen peroxideDNAdamaging

-0.416

Levo10 ug/mL LevofloxacinDNAdamaging

-0.232

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.501

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.499

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.461

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.409

Antimycin12.5-50 ug/mL Antimycin A?

0.788

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.281

PA_110-50 ug/mL Antitubercular compound PA-1?

0.556

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.614

PA8240.2-2 ug/mL PA-824?

-0.913

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.587

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.279

Verapamil50 uM Verapamil?

0.920

mercaptoethanol2 mM 2-Mercaptoethanol?

0.051

methoxatin10-20 ug/mL Methoxatin?