from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1783/eccC5

LFCtreatmentdescriptionclass of inhibitor

-1.594

Amikacinug/mL Amikacintranslation

-1.465

Cap5-10ug/mL Capreomycintranslation

-3.061

Rox10-50 ug/mL Roxithromycintranslation

-0.440

SM2-5 ug/mL Streptomycintranslation

-3.261

Tet5-10 ug/mL Tetracyclinetranslation

-0.947

Rif0.2-5ug/mL Rifampicintranscription

0.252

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.318

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.111

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.615

CPZ10-50 ug/mL Chlorpromazinerespiration

1.767

Clofazimine10-13 ug/mL Clofaziminerespiration

1.044

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.319

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.250

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.388

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.356

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.536

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.377

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.026

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.108

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.344

KCN5-20 ug/mL Potassium cyaniderespiration

-1.615

NaN30.2-2 mM Sodium aziderespiration

-0.604

Nigericin50 uM Nigericinrespiration

0.613

TRC10-150 ug/mL Triclosanrespiration

1.026

TRZ10-25 ug/mL Thioridazinerespiration

-0.645

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.385

menadione6-10 ug/mL Menadionerespiration

1.206

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.147

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.423

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.531

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.654

NRP_1Non-replicating persistence stage 1dosRassociated

0.575

Amp0.2mg/mL AmpicillincellWall

-0.016

Cephalexin20-100 ug/mL CephalexincellWall

0.305

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.512

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.211

EMB10-20 ug/mL EthambutolcellWall

0.634

Eta12-40 ug/mL EthionamidecellWall

0.801

INH0.2-0.4 ug/mL IsoniazidcellWall

0.498

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.796

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.795

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.845

BZA0.12 mg/mL BenzamidearomaticAmides

-0.014

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.222

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.492

H2O24 mM hydrogen peroxideDNAdamaging

-0.179

Levo10 ug/mL LevofloxacinDNAdamaging

-0.157

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.724

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.339

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.058

UVUV-irradiationDNAdamaging

-1.159

ARP41-4 ug/mL Antitubercular compound ARP4?

0.064

Antimycin12.5-50 ug/mL Antimycin A?

-0.250

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.573

PA_110-50 ug/mL Antitubercular compound PA-1?

0.002

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.388

PA8240.2-2 ug/mL PA-824?

0.768

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.004

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.286

Verapamil50 uM Verapamil?

-0.416

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.899

methoxatin10-20 ug/mL Methoxatin?