from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1750c/fadD1

LFCtreatmentdescriptionclass of inhibitor

0.136

Amikacinug/mL Amikacintranslation

0.841

Cap5-10ug/mL Capreomycintranslation

2.042

Rox10-50 ug/mL Roxithromycintranslation

0.381

SM2-5 ug/mL Streptomycintranslation

1.024

Tet5-10 ug/mL Tetracyclinetranslation

-0.282

Rif0.2-5ug/mL Rifampicintranscription

-0.875

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.998

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.521

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.062

CPZ10-50 ug/mL Chlorpromazinerespiration

0.275

Clofazimine10-13 ug/mL Clofaziminerespiration

0.740

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.817

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.892

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.105

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.469

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.268

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.440

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.309

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.260

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.136

KCN5-20 ug/mL Potassium cyaniderespiration

-0.438

NaN30.2-2 mM Sodium aziderespiration

-0.656

Nigericin50 uM Nigericinrespiration

-0.236

TRC10-150 ug/mL Triclosanrespiration

1.407

TRZ10-25 ug/mL Thioridazinerespiration

2.021

Valinomycin0.5-10 uM Valinomycinrespiration

-1.419

ZnSO42 mM ZnSO4respiration

0.340

menadione6-10 ug/mL Menadionerespiration

0.056

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.128

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.302

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.125

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.760

NRP_1Non-replicating persistence stage 1dosRassociated

-0.925

Amp0.2mg/mL AmpicillincellWall

-0.158

Cephalexin20-100 ug/mL CephalexincellWall

-0.289

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.141

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.654

EMB10-20 ug/mL EthambutolcellWall

-0.755

Eta12-40 ug/mL EthionamidecellWall

-0.466

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.617

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.297

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.414

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.256

BZA0.12 mg/mL BenzamidearomaticAmides

-0.705

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.320

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.032

H2O24 mM hydrogen peroxideDNAdamaging

-0.497

Levo10 ug/mL LevofloxacinDNAdamaging

-0.364

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.178

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.745

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.293

UVUV-irradiationDNAdamaging

-0.344

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.721

Antimycin12.5-50 ug/mL Antimycin A?

-0.072

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.326

PA_110-50 ug/mL Antitubercular compound PA-1?

0.235

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.996

PA8240.2-2 ug/mL PA-824?

-0.183

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.107

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.386

Verapamil50 uM Verapamil?

0.346

mercaptoethanol2 mM 2-Mercaptoethanol?

0.041

methoxatin10-20 ug/mL Methoxatin?