from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1736c/narX

LFCtreatmentdescriptionclass of inhibitor

-0.987

Amikacinug/mL Amikacintranslation

-0.915

Cap5-10ug/mL Capreomycintranslation

-0.396

Rox10-50 ug/mL Roxithromycintranslation

-0.908

SM2-5 ug/mL Streptomycintranslation

-0.541

Tet5-10 ug/mL Tetracyclinetranslation

1.044

Rif0.2-5ug/mL Rifampicintranscription

-0.418

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.268

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.315

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.286

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.528

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.426

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.530

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.180

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.541

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.427

Nigericin50 uM Nigericinrespiration

0.235

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.844

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.667

menadione6-10 ug/mL Menadionerespiration

0.663

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.476

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.150

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.558

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.867

NRP_1Non-replicating persistence stage 1dosRassociated

-0.017

Amp0.2mg/mL AmpicillincellWall

-0.075

Cephalexin20-100 ug/mL CephalexincellWall

-0.563

Cerulenin0.32-5 ug/mL CerulenincellWall

0.722

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.560

EMB10-20 ug/mL EthambutolcellWall

-0.924

Eta12-40 ug/mL EthionamidecellWall

-1.114

INH0.2-0.4 ug/mL IsoniazidcellWall

0.087

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-3.207

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.770

BZA0.12 mg/mL BenzamidearomaticAmides

-0.198

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.613

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.085

H2O24 mM hydrogen peroxideDNAdamaging

-0.365

Levo10 ug/mL LevofloxacinDNAdamaging

0.275

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.162

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.004

UVUV-irradiationDNAdamaging

-0.572

ARP41-4 ug/mL Antitubercular compound ARP4?

0.341

Antimycin12.5-50 ug/mL Antimycin A?

-1.282

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.491

PA_110-50 ug/mL Antitubercular compound PA-1?

0.145

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.752

PA8240.2-2 ug/mL PA-824?

1.144

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.622

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-1.389

mercaptoethanol2 mM 2-Mercaptoethanol?

1.274

methoxatin10-20 ug/mL Methoxatin?