from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1732c/-

LFCtreatmentdescriptionclass of inhibitor

-0.235

Amikacinug/mL Amikacintranslation

0.621

Cap5-10ug/mL Capreomycintranslation

0.105

Rox10-50 ug/mL Roxithromycintranslation

0.539

SM2-5 ug/mL Streptomycintranslation

1.185

Tet5-10 ug/mL Tetracyclinetranslation

-0.733

Rif0.2-5ug/mL Rifampicintranscription

-0.594

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.081

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.933

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.321

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.276

Clofazimine10-13 ug/mL Clofaziminerespiration

0.204

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.511

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.743

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.504

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.149

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.711

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.747

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.032

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

1.190

Nigericin50 uM Nigericinrespiration

0.795

TRC10-150 ug/mL Triclosanrespiration

0.098

TRZ10-25 ug/mL Thioridazinerespiration

0.600

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.735

menadione6-10 ug/mL Menadionerespiration

-0.678

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.308

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.261

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.291

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.033

NRP_1Non-replicating persistence stage 1dosRassociated

-0.018

Amp0.2mg/mL AmpicillincellWall

1.027

Cephalexin20-100 ug/mL CephalexincellWall

-0.215

Cerulenin0.32-5 ug/mL CerulenincellWall

0.606

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.490

EMB10-20 ug/mL EthambutolcellWall

-0.104

Eta12-40 ug/mL EthionamidecellWall

-0.758

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.142

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.213

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.562

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.033

BZA0.12 mg/mL BenzamidearomaticAmides

-0.485

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.731

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.298

H2O24 mM hydrogen peroxideDNAdamaging

0.292

Levo10 ug/mL LevofloxacinDNAdamaging

0.211

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.552

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.616

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.407

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.049

Antimycin12.5-50 ug/mL Antimycin A?

0.277

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.720

PA_110-50 ug/mL Antitubercular compound PA-1?

0.595

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.728

PA8240.2-2 ug/mL PA-824?

0.138

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.472

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.532

Verapamil50 uM Verapamil?

1.232

mercaptoethanol2 mM 2-Mercaptoethanol?

0.869

methoxatin10-20 ug/mL Methoxatin?