from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1719/-

LFCtreatmentdescriptionclass of inhibitor

0.145

Amikacinug/mL Amikacintranslation

-0.320

Cap5-10ug/mL Capreomycintranslation

-0.362

Rox10-50 ug/mL Roxithromycintranslation

-0.768

SM2-5 ug/mL Streptomycintranslation

-0.606

Tet5-10 ug/mL Tetracyclinetranslation

0.245

Rif0.2-5ug/mL Rifampicintranscription

1.063

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.158

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.486

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.168

CPZ10-50 ug/mL Chlorpromazinerespiration

1.317

Clofazimine10-13 ug/mL Clofaziminerespiration

0.249

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.900

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.532

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.315

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.306

Econazole10-24 ug/mL Econazole (azole drug)respiration

2.372

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.049

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.234

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.922

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.055

KCN5-20 ug/mL Potassium cyaniderespiration

0.034

NaN30.2-2 mM Sodium aziderespiration

-1.146

Nigericin50 uM Nigericinrespiration

0.887

TRC10-150 ug/mL Triclosanrespiration

0.619

TRZ10-25 ug/mL Thioridazinerespiration

-0.178

Valinomycin0.5-10 uM Valinomycinrespiration

-2.071

ZnSO42 mM ZnSO4respiration

-0.497

menadione6-10 ug/mL Menadionerespiration

1.358

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.294

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

1.162

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.012

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.781

NRP_1Non-replicating persistence stage 1dosRassociated

-0.718

Amp0.2mg/mL AmpicillincellWall

0.285

Cephalexin20-100 ug/mL CephalexincellWall

-0.368

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.209

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.479

EMB10-20 ug/mL EthambutolcellWall

-0.629

Eta12-40 ug/mL EthionamidecellWall

-0.814

INH0.2-0.4 ug/mL IsoniazidcellWall

0.269

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.005

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.050

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.064

BZA0.12 mg/mL BenzamidearomaticAmides

-0.022

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.474

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.527

H2O24 mM hydrogen peroxideDNAdamaging

0.112

Levo10 ug/mL LevofloxacinDNAdamaging

-0.309

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.482

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.234

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.815

UVUV-irradiationDNAdamaging

1.638

ARP41-4 ug/mL Antitubercular compound ARP4?

0.333

Antimycin12.5-50 ug/mL Antimycin A?

-0.160

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.488

PA_110-50 ug/mL Antitubercular compound PA-1?

0.464

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.183

PA8240.2-2 ug/mL PA-824?

0.757

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.372

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.467

Verapamil50 uM Verapamil?

0.180

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.195

methoxatin10-20 ug/mL Methoxatin?