from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1710/scpB

LFCtreatmentdescriptionclass of inhibitor

-0.285

Amikacinug/mL Amikacintranslation

0.580

Cap5-10ug/mL Capreomycintranslation

0.095

Rox10-50 ug/mL Roxithromycintranslation

-0.372

SM2-5 ug/mL Streptomycintranslation

-0.755

Tet5-10 ug/mL Tetracyclinetranslation

0.125

Rif0.2-5ug/mL Rifampicintranscription

-0.384

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-3.183

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.311

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.652

Clofazimine10-13 ug/mL Clofaziminerespiration

0.898

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.580

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.031

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.233

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.527

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.729

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

3.139

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.600

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.582

Nigericin50 uM Nigericinrespiration

0.529

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.052

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.501

menadione6-10 ug/mL Menadionerespiration

-0.718

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.594

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.516

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.693

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.168

NRP_1Non-replicating persistence stage 1dosRassociated

0.454

Amp0.2mg/mL AmpicillincellWall

0.276

Cephalexin20-100 ug/mL CephalexincellWall

-0.296

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.394

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.283

EMB10-20 ug/mL EthambutolcellWall

-0.242

Eta12-40 ug/mL EthionamidecellWall

-0.575

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.215

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.433

BZA0.12 mg/mL BenzamidearomaticAmides

0.236

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.105

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.221

H2O24 mM hydrogen peroxideDNAdamaging

0.333

Levo10 ug/mL LevofloxacinDNAdamaging

0.563

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.279

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.600

UVUV-irradiationDNAdamaging

0.689

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.118

Antimycin12.5-50 ug/mL Antimycin A?

-1.127

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.415

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.548

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.857

PA8240.2-2 ug/mL PA-824?

-0.737

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.343

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-2.689

mercaptoethanol2 mM 2-Mercaptoethanol?

0.032

methoxatin10-20 ug/mL Methoxatin?