from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1687c/-

LFCtreatmentdescriptionclass of inhibitor

-0.444

Amikacinug/mL Amikacintranslation

-0.059

Cap5-10ug/mL Capreomycintranslation

-0.082

Rox10-50 ug/mL Roxithromycintranslation

-0.435

SM2-5 ug/mL Streptomycintranslation

0.523

Tet5-10 ug/mL Tetracyclinetranslation

-0.060

Rif0.2-5ug/mL Rifampicintranscription

-0.178

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.384

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

4.016

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.404

CPZ10-50 ug/mL Chlorpromazinerespiration

0.022

Clofazimine10-13 ug/mL Clofaziminerespiration

0.199

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.309

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.957

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.188

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.270

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.490

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.414

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.191

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.326

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.277

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.148

Nigericin50 uM Nigericinrespiration

3.658

TRC10-150 ug/mL Triclosanrespiration

-0.653

TRZ10-25 ug/mL Thioridazinerespiration

0.647

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.336

menadione6-10 ug/mL Menadionerespiration

-0.237

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.481

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.231

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.230

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.577

NRP_1Non-replicating persistence stage 1dosRassociated

-0.493

Amp0.2mg/mL AmpicillincellWall

-0.405

Cephalexin20-100 ug/mL CephalexincellWall

-0.290

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.298

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.308

EMB10-20 ug/mL EthambutolcellWall

-0.365

Eta12-40 ug/mL EthionamidecellWall

-0.238

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.353

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.412

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.125

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.208

BZA0.12 mg/mL BenzamidearomaticAmides

-0.052

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.306

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.108

H2O24 mM hydrogen peroxideDNAdamaging

-0.340

Levo10 ug/mL LevofloxacinDNAdamaging

-0.467

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.891

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.374

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.356

UVUV-irradiationDNAdamaging

2.565

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.297

Antimycin12.5-50 ug/mL Antimycin A?

-0.230

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.427

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.460

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.326

PA8240.2-2 ug/mL PA-824?

-0.303

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.364

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.061

Verapamil50 uM Verapamil?

-0.578

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.451

methoxatin10-20 ug/mL Methoxatin?