from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1681/moeX

LFCtreatmentdescriptionclass of inhibitor

-0.264

Amikacinug/mL Amikacintranslation

-0.493

Cap5-10ug/mL Capreomycintranslation

-0.715

Rox10-50 ug/mL Roxithromycintranslation

-0.516

SM2-5 ug/mL Streptomycintranslation

0.282

Tet5-10 ug/mL Tetracyclinetranslation

-0.424

Rif0.2-5ug/mL Rifampicintranscription

0.082

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.193

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.347

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.764

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.468

Clofazimine10-13 ug/mL Clofaziminerespiration

0.146

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.222

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.188

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.471

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.163

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.761

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

2.639

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.327

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.385

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.702

KCN5-20 ug/mL Potassium cyaniderespiration

-0.147

NaN30.2-2 mM Sodium aziderespiration

0.313

Nigericin50 uM Nigericinrespiration

-0.624

TRC10-150 ug/mL Triclosanrespiration

-1.305

TRZ10-25 ug/mL Thioridazinerespiration

-0.981

Valinomycin0.5-10 uM Valinomycinrespiration

-0.814

ZnSO42 mM ZnSO4respiration

0.041

menadione6-10 ug/mL Menadionerespiration

0.253

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.020

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.045

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.026

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.921

NRP_1Non-replicating persistence stage 1dosRassociated

0.061

Amp0.2mg/mL AmpicillincellWall

-0.279

Cephalexin20-100 ug/mL CephalexincellWall

0.374

Cerulenin0.32-5 ug/mL CerulenincellWall

0.055

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.163

EMB10-20 ug/mL EthambutolcellWall

-0.120

Eta12-40 ug/mL EthionamidecellWall

-0.176

INH0.2-0.4 ug/mL IsoniazidcellWall

0.052

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.472

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.327

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.124

BZA0.12 mg/mL BenzamidearomaticAmides

-0.564

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.667

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.297

H2O24 mM hydrogen peroxideDNAdamaging

-0.055

Levo10 ug/mL LevofloxacinDNAdamaging

-0.044

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.714

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.001

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.207

UVUV-irradiationDNAdamaging

0.333

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.000

Antimycin12.5-50 ug/mL Antimycin A?

-0.182

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.136

PA_110-50 ug/mL Antitubercular compound PA-1?

0.086

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.044

PA8240.2-2 ug/mL PA-824?

-0.960

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.211

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.155

Verapamil50 uM Verapamil?

0.319

mercaptoethanol2 mM 2-Mercaptoethanol?

0.007

methoxatin10-20 ug/mL Methoxatin?