from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1661/pks7

LFCtreatmentdescriptionclass of inhibitor

-0.575

Amikacinug/mL Amikacintranslation

-1.034

Cap5-10ug/mL Capreomycintranslation

-1.168

Rox10-50 ug/mL Roxithromycintranslation

-0.742

SM2-5 ug/mL Streptomycintranslation

-0.865

Tet5-10 ug/mL Tetracyclinetranslation

0.948

Rif0.2-5ug/mL Rifampicintranscription

0.372

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.822

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.353

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.234

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.649

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.694

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.340

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.167

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.818

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.453

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.081

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.614

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.001

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.652

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.544

KCN5-20 ug/mL Potassium cyaniderespiration

-0.205

NaN30.2-2 mM Sodium aziderespiration

0.123

Nigericin50 uM Nigericinrespiration

0.506

TRC10-150 ug/mL Triclosanrespiration

0.066

TRZ10-25 ug/mL Thioridazinerespiration

0.839

Valinomycin0.5-10 uM Valinomycinrespiration

-1.408

ZnSO42 mM ZnSO4respiration

1.033

menadione6-10 ug/mL Menadionerespiration

-0.264

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.707

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.119

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.203

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.700

NRP_1Non-replicating persistence stage 1dosRassociated

-0.114

Amp0.2mg/mL AmpicillincellWall

-0.729

Cephalexin20-100 ug/mL CephalexincellWall

-0.696

Cerulenin0.32-5 ug/mL CerulenincellWall

1.470

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.336

EMB10-20 ug/mL EthambutolcellWall

-0.938

Eta12-40 ug/mL EthionamidecellWall

-1.371

INH0.2-0.4 ug/mL IsoniazidcellWall

0.327

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.152

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.671

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.677

BZA0.12 mg/mL BenzamidearomaticAmides

-0.004

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.200

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.209

H2O24 mM hydrogen peroxideDNAdamaging

-0.058

Levo10 ug/mL LevofloxacinDNAdamaging

0.287

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.281

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.474

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.614

UVUV-irradiationDNAdamaging

0.556

ARP41-4 ug/mL Antitubercular compound ARP4?

0.025

Antimycin12.5-50 ug/mL Antimycin A?

1.153

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.096

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.220

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.729

PA8240.2-2 ug/mL PA-824?

-0.352

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.654

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.497

Verapamil50 uM Verapamil?

0.658

mercaptoethanol2 mM 2-Mercaptoethanol?

0.120

methoxatin10-20 ug/mL Methoxatin?