from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1641/infC

LFCtreatmentdescriptionclass of inhibitor

1.938

Amikacinug/mL Amikacintranslation

1.064

Cap5-10ug/mL Capreomycintranslation

2.104

Rox10-50 ug/mL Roxithromycintranslation

0.530

SM2-5 ug/mL Streptomycintranslation

2.889

Tet5-10 ug/mL Tetracyclinetranslation

-0.252

Rif0.2-5ug/mL Rifampicintranscription

-0.035

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.026

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.327

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.102

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.024

Clofazimine10-13 ug/mL Clofaziminerespiration

0.023

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.188

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.535

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.333

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.055

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.419

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.017

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.111

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.989

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.637

KCN5-20 ug/mL Potassium cyaniderespiration

-1.483

NaN30.2-2 mM Sodium aziderespiration

-0.230

Nigericin50 uM Nigericinrespiration

-0.961

TRC10-150 ug/mL Triclosanrespiration

-1.605

TRZ10-25 ug/mL Thioridazinerespiration

0.146

Valinomycin0.5-10 uM Valinomycinrespiration

-0.098

ZnSO42 mM ZnSO4respiration

-1.394

menadione6-10 ug/mL Menadionerespiration

0.023

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.040

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.046

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.094

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.573

NRP_1Non-replicating persistence stage 1dosRassociated

0.677

Amp0.2mg/mL AmpicillincellWall

0.376

Cephalexin20-100 ug/mL CephalexincellWall

0.013

Cerulenin0.32-5 ug/mL CerulenincellWall

0.174

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.697

EMB10-20 ug/mL EthambutolcellWall

0.538

Eta12-40 ug/mL EthionamidecellWall

0.812

INH0.2-0.4 ug/mL IsoniazidcellWall

0.652

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.643

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.671

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.049

BZA0.12 mg/mL BenzamidearomaticAmides

-0.138

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.077

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.177

H2O24 mM hydrogen peroxideDNAdamaging

-0.016

Levo10 ug/mL LevofloxacinDNAdamaging

0.544

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.091

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.384

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.650

UVUV-irradiationDNAdamaging

-2.287

ARP41-4 ug/mL Antitubercular compound ARP4?

0.227

Antimycin12.5-50 ug/mL Antimycin A?

-0.091

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.271

PA_110-50 ug/mL Antitubercular compound PA-1?

0.283

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.925

PA8240.2-2 ug/mL PA-824?

-0.134

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.570

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.479

Verapamil50 uM Verapamil?

0.144

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.357

methoxatin10-20 ug/mL Methoxatin?