from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1637c/-

LFCtreatmentdescriptionclass of inhibitor

2.234

Amikacinug/mL Amikacintranslation

2.175

Cap5-10ug/mL Capreomycintranslation

1.468

Rox10-50 ug/mL Roxithromycintranslation

0.313

SM2-5 ug/mL Streptomycintranslation

2.022

Tet5-10 ug/mL Tetracyclinetranslation

-2.045

Rif0.2-5ug/mL Rifampicintranscription

0.027

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.825

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.975

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.074

CPZ10-50 ug/mL Chlorpromazinerespiration

0.656

Clofazimine10-13 ug/mL Clofaziminerespiration

0.194

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.816

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.472

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.188

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.679

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.008

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.091

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.119

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.853

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.931

KCN5-20 ug/mL Potassium cyaniderespiration

-0.080

NaN30.2-2 mM Sodium aziderespiration

0.490

Nigericin50 uM Nigericinrespiration

-0.649

TRC10-150 ug/mL Triclosanrespiration

-0.261

TRZ10-25 ug/mL Thioridazinerespiration

-0.066

Valinomycin0.5-10 uM Valinomycinrespiration

1.293

ZnSO42 mM ZnSO4respiration

0.617

menadione6-10 ug/mL Menadionerespiration

0.696

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.492

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.787

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.368

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.568

NRP_1Non-replicating persistence stage 1dosRassociated

-0.218

Amp0.2mg/mL AmpicillincellWall

-0.304

Cephalexin20-100 ug/mL CephalexincellWall

0.652

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.508

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.160

EMB10-20 ug/mL EthambutolcellWall

1.498

Eta12-40 ug/mL EthionamidecellWall

1.147

INH0.2-0.4 ug/mL IsoniazidcellWall

1.376

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.248

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.111

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.170

BZA0.12 mg/mL BenzamidearomaticAmides

-0.480

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.042

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.074

H2O24 mM hydrogen peroxideDNAdamaging

-0.227

Levo10 ug/mL LevofloxacinDNAdamaging

-0.403

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.107

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.363

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.555

UVUV-irradiationDNAdamaging

0.394

ARP41-4 ug/mL Antitubercular compound ARP4?

0.681

Antimycin12.5-50 ug/mL Antimycin A?

-0.105

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.899

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.640

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.441

PA8240.2-2 ug/mL PA-824?

-0.686

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.201

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.799

Verapamil50 uM Verapamil?

0.283

mercaptoethanol2 mM 2-Mercaptoethanol?

0.411

methoxatin10-20 ug/mL Methoxatin?