from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1567c/-

LFCtreatmentdescriptionclass of inhibitor

0.182

Amikacinug/mL Amikacintranslation

0.312

Cap5-10ug/mL Capreomycintranslation

0.289

Rox10-50 ug/mL Roxithromycintranslation

-0.310

SM2-5 ug/mL Streptomycintranslation

0.207

Tet5-10 ug/mL Tetracyclinetranslation

1.376

Rif0.2-5ug/mL Rifampicintranscription

-0.357

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.665

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.199

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.535

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.502

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.343

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.883

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.517

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.523

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.278

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.047

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.964

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.422

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.282

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.923

KCN5-20 ug/mL Potassium cyaniderespiration

0.076

NaN30.2-2 mM Sodium aziderespiration

0.304

Nigericin50 uM Nigericinrespiration

-0.225

TRC10-150 ug/mL Triclosanrespiration

-0.677

TRZ10-25 ug/mL Thioridazinerespiration

0.136

Valinomycin0.5-10 uM Valinomycinrespiration

0.592

ZnSO42 mM ZnSO4respiration

-0.533

menadione6-10 ug/mL Menadionerespiration

-0.320

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.242

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.185

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.273

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.347

NRP_1Non-replicating persistence stage 1dosRassociated

-0.311

Amp0.2mg/mL AmpicillincellWall

-0.229

Cephalexin20-100 ug/mL CephalexincellWall

0.252

Cerulenin0.32-5 ug/mL CerulenincellWall

1.501

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.840

EMB10-20 ug/mL EthambutolcellWall

0.345

Eta12-40 ug/mL EthionamidecellWall

0.174

INH0.2-0.4 ug/mL IsoniazidcellWall

0.176

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.082

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.666

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.234

BZA0.12 mg/mL BenzamidearomaticAmides

0.175

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.355

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.667

H2O24 mM hydrogen peroxideDNAdamaging

0.216

Levo10 ug/mL LevofloxacinDNAdamaging

-0.269

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.257

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.500

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.446

UVUV-irradiationDNAdamaging

0.942

ARP41-4 ug/mL Antitubercular compound ARP4?

0.093

Antimycin12.5-50 ug/mL Antimycin A?

-0.159

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.387

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.475

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.902

PA8240.2-2 ug/mL PA-824?

-0.784

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.050

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.178

Verapamil50 uM Verapamil?

-0.034

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.127

methoxatin10-20 ug/mL Methoxatin?