from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1560/vapB11

LFCtreatmentdescriptionclass of inhibitor

0.475

Amikacinug/mL Amikacintranslation

0.874

Cap5-10ug/mL Capreomycintranslation

1.354

Rox10-50 ug/mL Roxithromycintranslation

0.802

SM2-5 ug/mL Streptomycintranslation

1.274

Tet5-10 ug/mL Tetracyclinetranslation

0.322

Rif0.2-5ug/mL Rifampicintranscription

0.473

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.132

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.677

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.076

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.240

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.366

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.606

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.620

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.079

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.174

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.558

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.823

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.435

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.386

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.687

KCN5-20 ug/mL Potassium cyaniderespiration

0.273

NaN30.2-2 mM Sodium aziderespiration

0.167

Nigericin50 uM Nigericinrespiration

-0.103

TRC10-150 ug/mL Triclosanrespiration

-0.682

TRZ10-25 ug/mL Thioridazinerespiration

2.911

Valinomycin0.5-10 uM Valinomycinrespiration

0.897

ZnSO42 mM ZnSO4respiration

1.384

menadione6-10 ug/mL Menadionerespiration

-0.256

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.220

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.337

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.016

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.944

NRP_1Non-replicating persistence stage 1dosRassociated

0.284

Amp0.2mg/mL AmpicillincellWall

0.250

Cephalexin20-100 ug/mL CephalexincellWall

0.661

Cerulenin0.32-5 ug/mL CerulenincellWall

0.099

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.160

EMB10-20 ug/mL EthambutolcellWall

0.802

Eta12-40 ug/mL EthionamidecellWall

1.542

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.001

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.317

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.309

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.392

BZA0.12 mg/mL BenzamidearomaticAmides

-0.200

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.340

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.293

H2O24 mM hydrogen peroxideDNAdamaging

-0.009

Levo10 ug/mL LevofloxacinDNAdamaging

-0.123

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.736

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.173

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.800

UVUV-irradiationDNAdamaging

-0.224

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.855

Antimycin12.5-50 ug/mL Antimycin A?

0.011

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.208

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.635

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.150

PA8240.2-2 ug/mL PA-824?

-0.347

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.087

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.383

Verapamil50 uM Verapamil?

0.407

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.345

methoxatin10-20 ug/mL Methoxatin?