from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1550/fadD11

LFCtreatmentdescriptionclass of inhibitor

0.228

Amikacinug/mL Amikacintranslation

0.423

Cap5-10ug/mL Capreomycintranslation

0.254

Rox10-50 ug/mL Roxithromycintranslation

0.458

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

1.562

Rif0.2-5ug/mL Rifampicintranscription

0.703

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.389

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.436

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.409

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.841

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.327

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.508

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.118

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.575

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.543

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.065

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.463

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.724

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.347

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.520

Nigericin50 uM Nigericinrespiration

0.778

TRC10-150 ug/mL Triclosanrespiration

-0.326

TRZ10-25 ug/mL Thioridazinerespiration

-0.694

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.560

menadione6-10 ug/mL Menadionerespiration

-0.079

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-1.075

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.267

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.363

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.715

NRP_1Non-replicating persistence stage 1dosRassociated

0.170

Amp0.2mg/mL AmpicillincellWall

-0.267

Cephalexin20-100 ug/mL CephalexincellWall

0.299

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.480

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.754

EMB10-20 ug/mL EthambutolcellWall

0.084

Eta12-40 ug/mL EthionamidecellWall

-0.868

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.503

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.120

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.108

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.540

BZA0.12 mg/mL BenzamidearomaticAmides

0.489

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.203

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.200

H2O24 mM hydrogen peroxideDNAdamaging

0.188

Levo10 ug/mL LevofloxacinDNAdamaging

0.356

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.037

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.178

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.277

UVUV-irradiationDNAdamaging

-0.453

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.532

Antimycin12.5-50 ug/mL Antimycin A?

0.266

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.284

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.651

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.558

PA8240.2-2 ug/mL PA-824?

-1.305

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.515

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.404

Verapamil50 uM Verapamil?

0.551

mercaptoethanol2 mM 2-Mercaptoethanol?

0.167

methoxatin10-20 ug/mL Methoxatin?