from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1549/fadD11.1

LFCtreatmentdescriptionclass of inhibitor

0.462

Amikacinug/mL Amikacintranslation

0.250

Cap5-10ug/mL Capreomycintranslation

-0.626

Rox10-50 ug/mL Roxithromycintranslation

-0.514

SM2-5 ug/mL Streptomycintranslation

-0.074

Tet5-10 ug/mL Tetracyclinetranslation

0.539

Rif0.2-5ug/mL Rifampicintranscription

0.665

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.381

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.743

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.545

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.799

Clofazimine10-13 ug/mL Clofaziminerespiration

-1.112

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.623

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.082

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.998

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.567

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.399

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.912

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.964

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.405

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.288

KCN5-20 ug/mL Potassium cyaniderespiration

-1.145

NaN30.2-2 mM Sodium aziderespiration

0.501

Nigericin50 uM Nigericinrespiration

-0.081

TRC10-150 ug/mL Triclosanrespiration

-1.082

TRZ10-25 ug/mL Thioridazinerespiration

-1.780

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.163

menadione6-10 ug/mL Menadionerespiration

-0.793

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.285

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.403

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.332

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.645

NRP_1Non-replicating persistence stage 1dosRassociated

0.071

Amp0.2mg/mL AmpicillincellWall

0.526

Cephalexin20-100 ug/mL CephalexincellWall

-0.619

Cerulenin0.32-5 ug/mL CerulenincellWall

0.345

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.220

EMB10-20 ug/mL EthambutolcellWall

0.266

Eta12-40 ug/mL EthionamidecellWall

-0.020

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.250

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.074

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.314

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.983

BZA0.12 mg/mL BenzamidearomaticAmides

0.957

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.636

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.006

H2O24 mM hydrogen peroxideDNAdamaging

0.379

Levo10 ug/mL LevofloxacinDNAdamaging

0.311

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.908

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.137

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.121

UVUV-irradiationDNAdamaging

-0.341

ARP41-4 ug/mL Antitubercular compound ARP4?

0.419

Antimycin12.5-50 ug/mL Antimycin A?

0.265

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.461

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.297

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.756

PA8240.2-2 ug/mL PA-824?

-2.053

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.149

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.545

Verapamil50 uM Verapamil?

0.573

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.004

methoxatin10-20 ug/mL Methoxatin?