from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1537/dinX

LFCtreatmentdescriptionclass of inhibitor

0.728

Amikacinug/mL Amikacintranslation

0.722

Cap5-10ug/mL Capreomycintranslation

0.153

Rox10-50 ug/mL Roxithromycintranslation

-0.228

SM2-5 ug/mL Streptomycintranslation

0.561

Tet5-10 ug/mL Tetracyclinetranslation

2.206

Rif0.2-5ug/mL Rifampicintranscription

0.563

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.558

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.707

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.247

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.148

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.879

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.010

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.790

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.355

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.945

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.221

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.098

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.889

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.251

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.420

KCN5-20 ug/mL Potassium cyaniderespiration

-1.876

NaN30.2-2 mM Sodium aziderespiration

-0.395

Nigericin50 uM Nigericinrespiration

0.269

TRC10-150 ug/mL Triclosanrespiration

-1.396

TRZ10-25 ug/mL Thioridazinerespiration

-0.227

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

1.019

menadione6-10 ug/mL Menadionerespiration

-0.601

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.249

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.594

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.844

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.224

NRP_1Non-replicating persistence stage 1dosRassociated

-0.843

Amp0.2mg/mL AmpicillincellWall

-0.344

Cephalexin20-100 ug/mL CephalexincellWall

0.075

Cerulenin0.32-5 ug/mL CerulenincellWall

0.640

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.474

EMB10-20 ug/mL EthambutolcellWall

-0.397

Eta12-40 ug/mL EthionamidecellWall

-0.305

INH0.2-0.4 ug/mL IsoniazidcellWall

0.454

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.664

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.649

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.363

BZA0.12 mg/mL BenzamidearomaticAmides

0.688

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.108

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.340

H2O24 mM hydrogen peroxideDNAdamaging

0.106

Levo10 ug/mL LevofloxacinDNAdamaging

-0.090

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.789

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.341

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.971

UVUV-irradiationDNAdamaging

-0.697

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.366

Antimycin12.5-50 ug/mL Antimycin A?

0.569

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.824

PA_110-50 ug/mL Antitubercular compound PA-1?

0.020

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.196

PA8240.2-2 ug/mL PA-824?

0.832

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.683

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.632

Verapamil50 uM Verapamil?

0.089

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.893

methoxatin10-20 ug/mL Methoxatin?