from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1526c/-

LFCtreatmentdescriptionclass of inhibitor

-0.823

Amikacinug/mL Amikacintranslation

1.147

Cap5-10ug/mL Capreomycintranslation

-0.543

Rox10-50 ug/mL Roxithromycintranslation

1.297

SM2-5 ug/mL Streptomycintranslation

0.352

Tet5-10 ug/mL Tetracyclinetranslation

-0.215

Rif0.2-5ug/mL Rifampicintranscription

0.598

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.309

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.592

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.771

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.427

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.717

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.358

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.203

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.303

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.294

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.490

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.155

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.446

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.651

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.341

KCN5-20 ug/mL Potassium cyaniderespiration

0.255

NaN30.2-2 mM Sodium aziderespiration

-1.095

Nigericin50 uM Nigericinrespiration

0.318

TRC10-150 ug/mL Triclosanrespiration

-0.309

TRZ10-25 ug/mL Thioridazinerespiration

-0.693

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.486

menadione6-10 ug/mL Menadionerespiration

0.236

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.089

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.011

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.341

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.103

NRP_1Non-replicating persistence stage 1dosRassociated

0.653

Amp0.2mg/mL AmpicillincellWall

0.278

Cephalexin20-100 ug/mL CephalexincellWall

0.871

Cerulenin0.32-5 ug/mL CerulenincellWall

0.819

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.273

EMB10-20 ug/mL EthambutolcellWall

0.582

Eta12-40 ug/mL EthionamidecellWall

-1.415

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.010

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.182

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.141

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.428

BZA0.12 mg/mL BenzamidearomaticAmides

0.433

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.198

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.771

H2O24 mM hydrogen peroxideDNAdamaging

0.864

Levo10 ug/mL LevofloxacinDNAdamaging

1.051

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.218

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.535

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.323

UVUV-irradiationDNAdamaging

-0.403

ARP41-4 ug/mL Antitubercular compound ARP4?

0.492

Antimycin12.5-50 ug/mL Antimycin A?

-0.147

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.256

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.309

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.673

PA8240.2-2 ug/mL PA-824?

-0.711

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.122

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.582

Verapamil50 uM Verapamil?

-0.049

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.513

methoxatin10-20 ug/mL Methoxatin?