from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1426c/lipO

LFCtreatmentdescriptionclass of inhibitor

-0.505

Amikacinug/mL Amikacintranslation

-1.789

Cap5-10ug/mL Capreomycintranslation

-2.250

Rox10-50 ug/mL Roxithromycintranslation

-0.463

SM2-5 ug/mL Streptomycintranslation

-1.889

Tet5-10 ug/mL Tetracyclinetranslation

0.690

Rif0.2-5ug/mL Rifampicintranscription

-0.587

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.937

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.263

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.191

CPZ10-50 ug/mL Chlorpromazinerespiration

0.343

Clofazimine10-13 ug/mL Clofaziminerespiration

0.639

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.334

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.284

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.442

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.492

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.426

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.782

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.674

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.980

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.020

KCN5-20 ug/mL Potassium cyaniderespiration

0.748

NaN30.2-2 mM Sodium aziderespiration

-0.224

Nigericin50 uM Nigericinrespiration

-0.368

TRC10-150 ug/mL Triclosanrespiration

-1.891

TRZ10-25 ug/mL Thioridazinerespiration

-1.577

Valinomycin0.5-10 uM Valinomycinrespiration

1.060

ZnSO42 mM ZnSO4respiration

-0.692

menadione6-10 ug/mL Menadionerespiration

-0.076

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.356

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.120

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.501

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.625

NRP_1Non-replicating persistence stage 1dosRassociated

0.472

Amp0.2mg/mL AmpicillincellWall

0.380

Cephalexin20-100 ug/mL CephalexincellWall

-0.348

Cerulenin0.32-5 ug/mL CerulenincellWall

0.600

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.389

EMB10-20 ug/mL EthambutolcellWall

0.299

Eta12-40 ug/mL EthionamidecellWall

0.066

INH0.2-0.4 ug/mL IsoniazidcellWall

0.146

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.788

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.187

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.207

BZA0.12 mg/mL BenzamidearomaticAmides

0.513

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.252

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.118

H2O24 mM hydrogen peroxideDNAdamaging

0.133

Levo10 ug/mL LevofloxacinDNAdamaging

0.554

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.869

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.330

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.184

UVUV-irradiationDNAdamaging

-1.040

ARP41-4 ug/mL Antitubercular compound ARP4?

0.702

Antimycin12.5-50 ug/mL Antimycin A?

0.633

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.891

PA_110-50 ug/mL Antitubercular compound PA-1?

1.188

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.233

PA8240.2-2 ug/mL PA-824?

-0.804

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.062

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.355

Verapamil50 uM Verapamil?

0.552

mercaptoethanol2 mM 2-Mercaptoethanol?

0.557

methoxatin10-20 ug/mL Methoxatin?