from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1378c/-

LFCtreatmentdescriptionclass of inhibitor

0.607

Amikacinug/mL Amikacintranslation

0.159

Cap5-10ug/mL Capreomycintranslation

0.306

Rox10-50 ug/mL Roxithromycintranslation

-0.251

SM2-5 ug/mL Streptomycintranslation

1.398

Tet5-10 ug/mL Tetracyclinetranslation

0.843

Rif0.2-5ug/mL Rifampicintranscription

0.252

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.434

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.132

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.908

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.467

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.152

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.860

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.448

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.304

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.659

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.728

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.037

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.012

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.637

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.499

Nigericin50 uM Nigericinrespiration

-0.016

TRC10-150 ug/mL Triclosanrespiration

-0.219

TRZ10-25 ug/mL Thioridazinerespiration

-0.739

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.938

menadione6-10 ug/mL Menadionerespiration

-0.080

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.025

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.035

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.531

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.109

NRP_1Non-replicating persistence stage 1dosRassociated

-0.255

Amp0.2mg/mL AmpicillincellWall

-0.290

Cephalexin20-100 ug/mL CephalexincellWall

0.742

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.156

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.639

EMB10-20 ug/mL EthambutolcellWall

-0.261

Eta12-40 ug/mL EthionamidecellWall

0.303

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.470

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.191

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.575

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.732

BZA0.12 mg/mL BenzamidearomaticAmides

-0.040

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.351

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.193

H2O24 mM hydrogen peroxideDNAdamaging

0.218

Levo10 ug/mL LevofloxacinDNAdamaging

0.270

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.318

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.072

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.233

UVUV-irradiationDNAdamaging

-1.475

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.290

Antimycin12.5-50 ug/mL Antimycin A?

-0.059

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.069

PA_110-50 ug/mL Antitubercular compound PA-1?

0.088

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.886

PA8240.2-2 ug/mL PA-824?

-0.136

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.648

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.603

Verapamil50 uM Verapamil?

-0.966

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.415

methoxatin10-20 ug/mL Methoxatin?