from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1365c/rsfA

LFCtreatmentdescriptionclass of inhibitor

1.446

Amikacinug/mL Amikacintranslation

1.913

Cap5-10ug/mL Capreomycintranslation

2.181

Rox10-50 ug/mL Roxithromycintranslation

0.527

SM2-5 ug/mL Streptomycintranslation

0.994

Tet5-10 ug/mL Tetracyclinetranslation

-0.696

Rif0.2-5ug/mL Rifampicintranscription

-0.352

Rifp0.1-0.5ug/mL Rifapentinetranscription

4.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.806

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.555

CPZ10-50 ug/mL Chlorpromazinerespiration

0.711

Clofazimine10-13 ug/mL Clofaziminerespiration

0.510

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.089

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.302

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.205

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.009

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.463

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.508

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.186

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.602

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.398

KCN5-20 ug/mL Potassium cyaniderespiration

-0.094

NaN30.2-2 mM Sodium aziderespiration

0.890

Nigericin50 uM Nigericinrespiration

-0.625

TRC10-150 ug/mL Triclosanrespiration

0.532

TRZ10-25 ug/mL Thioridazinerespiration

0.282

Valinomycin0.5-10 uM Valinomycinrespiration

1.385

ZnSO42 mM ZnSO4respiration

-0.340

menadione6-10 ug/mL Menadionerespiration

0.294

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.037

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.274

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.544

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

2.099

NRP_1Non-replicating persistence stage 1dosRassociated

0.109

Amp0.2mg/mL AmpicillincellWall

-0.225

Cephalexin20-100 ug/mL CephalexincellWall

-0.257

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.093

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.141

EMB10-20 ug/mL EthambutolcellWall

-0.263

Eta12-40 ug/mL EthionamidecellWall

-0.157

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.317

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.434

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.070

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.479

BZA0.12 mg/mL BenzamidearomaticAmides

-0.748

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.428

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.909

H2O24 mM hydrogen peroxideDNAdamaging

0.630

Levo10 ug/mL LevofloxacinDNAdamaging

-0.654

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.259

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.062

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.309

UVUV-irradiationDNAdamaging

1.795

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.039

Antimycin12.5-50 ug/mL Antimycin A?

0.206

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.552

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.852

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.084

PA8240.2-2 ug/mL PA-824?

-0.658

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.703

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.533

Verapamil50 uM Verapamil?

0.166

mercaptoethanol2 mM 2-Mercaptoethanol?

0.064

methoxatin10-20 ug/mL Methoxatin?