from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1364c/-

LFCtreatmentdescriptionclass of inhibitor

0.135

Amikacinug/mL Amikacintranslation

1.082

Cap5-10ug/mL Capreomycintranslation

2.786

Rox10-50 ug/mL Roxithromycintranslation

-0.769

SM2-5 ug/mL Streptomycintranslation

-0.010

Tet5-10 ug/mL Tetracyclinetranslation

-0.183

Rif0.2-5ug/mL Rifampicintranscription

-0.202

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.206

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.692

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.782

CPZ10-50 ug/mL Chlorpromazinerespiration

1.195

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.070

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.813

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.287

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.460

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.505

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.597

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.996

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.829

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.069

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.085

KCN5-20 ug/mL Potassium cyaniderespiration

-0.545

NaN30.2-2 mM Sodium aziderespiration

0.624

Nigericin50 uM Nigericinrespiration

-0.051

TRC10-150 ug/mL Triclosanrespiration

1.143

TRZ10-25 ug/mL Thioridazinerespiration

1.751

Valinomycin0.5-10 uM Valinomycinrespiration

1.345

ZnSO42 mM ZnSO4respiration

0.044

menadione6-10 ug/mL Menadionerespiration

-0.018

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.522

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.407

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.021

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.089

NRP_1Non-replicating persistence stage 1dosRassociated

-1.117

Amp0.2mg/mL AmpicillincellWall

-0.325

Cephalexin20-100 ug/mL CephalexincellWall

-0.477

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.698

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.349

EMB10-20 ug/mL EthambutolcellWall

-0.660

Eta12-40 ug/mL EthionamidecellWall

-0.356

INH0.2-0.4 ug/mL IsoniazidcellWall

-1.080

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.061

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.194

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.976

BZA0.12 mg/mL BenzamidearomaticAmides

-0.619

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.590

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.397

H2O24 mM hydrogen peroxideDNAdamaging

-0.659

Levo10 ug/mL LevofloxacinDNAdamaging

-0.455

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.917

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.866

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.270

UVUV-irradiationDNAdamaging

1.222

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.537

Antimycin12.5-50 ug/mL Antimycin A?

-0.135

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.939

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.714

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.990

PA8240.2-2 ug/mL PA-824?

0.760

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.242

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.496

Verapamil50 uM Verapamil?

-0.198

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.076

methoxatin10-20 ug/mL Methoxatin?