from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1362c/-

LFCtreatmentdescriptionclass of inhibitor

-0.898

Amikacinug/mL Amikacintranslation

-0.209

Cap5-10ug/mL Capreomycintranslation

-1.465

Rox10-50 ug/mL Roxithromycintranslation

0.030

SM2-5 ug/mL Streptomycintranslation

0.153

Tet5-10 ug/mL Tetracyclinetranslation

-0.788

Rif0.2-5ug/mL Rifampicintranscription

0.047

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.850

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.874

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.872

CPZ10-50 ug/mL Chlorpromazinerespiration

0.157

Clofazimine10-13 ug/mL Clofaziminerespiration

0.629

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.758

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.587

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.533

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.385

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.276

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.220

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.120

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.097

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.021

KCN5-20 ug/mL Potassium cyaniderespiration

0.032

NaN30.2-2 mM Sodium aziderespiration

1.564

Nigericin50 uM Nigericinrespiration

-0.986

TRC10-150 ug/mL Triclosanrespiration

0.360

TRZ10-25 ug/mL Thioridazinerespiration

-1.584

Valinomycin0.5-10 uM Valinomycinrespiration

1.385

ZnSO42 mM ZnSO4respiration

1.096

menadione6-10 ug/mL Menadionerespiration

0.154

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.006

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.424

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.385

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.894

NRP_1Non-replicating persistence stage 1dosRassociated

0.429

Amp0.2mg/mL AmpicillincellWall

0.056

Cephalexin20-100 ug/mL CephalexincellWall

-0.349

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.009

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.073

EMB10-20 ug/mL EthambutolcellWall

0.189

Eta12-40 ug/mL EthionamidecellWall

-0.275

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.087

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.191

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.089

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.558

BZA0.12 mg/mL BenzamidearomaticAmides

-0.063

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.002

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.031

H2O24 mM hydrogen peroxideDNAdamaging

0.292

Levo10 ug/mL LevofloxacinDNAdamaging

0.466

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.833

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.327

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.412

UVUV-irradiationDNAdamaging

0.018

ARP41-4 ug/mL Antitubercular compound ARP4?

0.010

Antimycin12.5-50 ug/mL Antimycin A?

0.931

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.340

PA_110-50 ug/mL Antitubercular compound PA-1?

1.280

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.450

PA8240.2-2 ug/mL PA-824?

-0.586

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.160

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.336

Verapamil50 uM Verapamil?

0.880

mercaptoethanol2 mM 2-Mercaptoethanol?

0.193

methoxatin10-20 ug/mL Methoxatin?