from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1329c/dinG

LFCtreatmentdescriptionclass of inhibitor

-0.128

Amikacinug/mL Amikacintranslation

0.347

Cap5-10ug/mL Capreomycintranslation

0.827

Rox10-50 ug/mL Roxithromycintranslation

0.272

SM2-5 ug/mL Streptomycintranslation

-0.120

Tet5-10 ug/mL Tetracyclinetranslation

0.056

Rif0.2-5ug/mL Rifampicintranscription

0.800

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.084

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.536

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.137

CPZ10-50 ug/mL Chlorpromazinerespiration

0.353

Clofazimine10-13 ug/mL Clofaziminerespiration

0.873

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.071

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.317

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.727

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.393

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.254

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.384

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.908

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.197

KCN5-20 ug/mL Potassium cyaniderespiration

-0.395

NaN30.2-2 mM Sodium aziderespiration

-1.174

Nigericin50 uM Nigericinrespiration

-0.408

TRC10-150 ug/mL Triclosanrespiration

-0.249

TRZ10-25 ug/mL Thioridazinerespiration

-2.577

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.507

menadione6-10 ug/mL Menadionerespiration

0.248

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.433

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.240

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.098

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.073

NRP_1Non-replicating persistence stage 1dosRassociated

0.384

Amp0.2mg/mL AmpicillincellWall

0.288

Cephalexin20-100 ug/mL CephalexincellWall

0.839

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.118

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.268

EMB10-20 ug/mL EthambutolcellWall

0.836

Eta12-40 ug/mL EthionamidecellWall

1.186

INH0.2-0.4 ug/mL IsoniazidcellWall

0.635

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.292

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.175

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.028

BZA0.12 mg/mL BenzamidearomaticAmides

-0.137

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.029

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.269

H2O24 mM hydrogen peroxideDNAdamaging

0.130

Levo10 ug/mL LevofloxacinDNAdamaging

0.595

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.078

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.145

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.077

UVUV-irradiationDNAdamaging

-0.726

ARP41-4 ug/mL Antitubercular compound ARP4?

0.223

Antimycin12.5-50 ug/mL Antimycin A?

-0.665

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.321

PA_110-50 ug/mL Antitubercular compound PA-1?

0.107

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.568

PA8240.2-2 ug/mL PA-824?

-0.171

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.542

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.309

Verapamil50 uM Verapamil?

-0.700

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.037

methoxatin10-20 ug/mL Methoxatin?