from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1327c/glgE

LFCtreatmentdescriptionclass of inhibitor

-0.148

Amikacinug/mL Amikacintranslation

-1.333

Cap5-10ug/mL Capreomycintranslation

-2.063

Rox10-50 ug/mL Roxithromycintranslation

0.310

SM2-5 ug/mL Streptomycintranslation

-1.013

Tet5-10 ug/mL Tetracyclinetranslation

-1.043

Rif0.2-5ug/mL Rifampicintranscription

-0.944

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.295

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.065

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.726

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.238

Clofazimine10-13 ug/mL Clofaziminerespiration

0.426

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.399

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.040

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.451

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.202

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.587

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.763

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.051

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.198

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.143

KCN5-20 ug/mL Potassium cyaniderespiration

1.199

NaN30.2-2 mM Sodium aziderespiration

-2.813

Nigericin50 uM Nigericinrespiration

0.628

TRC10-150 ug/mL Triclosanrespiration

0.090

TRZ10-25 ug/mL Thioridazinerespiration

-1.325

Valinomycin0.5-10 uM Valinomycinrespiration

0.271

ZnSO42 mM ZnSO4respiration

-0.115

menadione6-10 ug/mL Menadionerespiration

-0.136

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.093

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.125

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.184

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.269

NRP_1Non-replicating persistence stage 1dosRassociated

-0.046

Amp0.2mg/mL AmpicillincellWall

0.145

Cephalexin20-100 ug/mL CephalexincellWall

-0.348

Cerulenin0.32-5 ug/mL CerulenincellWall

0.136

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.656

EMB10-20 ug/mL EthambutolcellWall

0.112

Eta12-40 ug/mL EthionamidecellWall

-0.296

INH0.2-0.4 ug/mL IsoniazidcellWall

0.351

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.355

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.707

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.672

BZA0.12 mg/mL BenzamidearomaticAmides

0.666

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.510

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.397

H2O24 mM hydrogen peroxideDNAdamaging

-0.737

Levo10 ug/mL LevofloxacinDNAdamaging

0.024

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.144

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.271

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.682

UVUV-irradiationDNAdamaging

-0.930

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.212

Antimycin12.5-50 ug/mL Antimycin A?

-0.465

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.188

PA_110-50 ug/mL Antitubercular compound PA-1?

0.309

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.116

PA8240.2-2 ug/mL PA-824?

1.434

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.616

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.044

Verapamil50 uM Verapamil?

0.530

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.661

methoxatin10-20 ug/mL Methoxatin?