from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1320c/-

LFCtreatmentdescriptionclass of inhibitor

-0.686

Amikacinug/mL Amikacintranslation

0.291

Cap5-10ug/mL Capreomycintranslation

1.226

Rox10-50 ug/mL Roxithromycintranslation

-0.216

SM2-5 ug/mL Streptomycintranslation

-0.764

Tet5-10 ug/mL Tetracyclinetranslation

0.251

Rif0.2-5ug/mL Rifampicintranscription

0.531

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.653

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.912

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.757

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.103

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.266

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.317

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.756

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.164

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.314

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.475

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.224

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.050

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.987

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.471

KCN5-20 ug/mL Potassium cyaniderespiration

0.308

NaN30.2-2 mM Sodium aziderespiration

-1.137

Nigericin50 uM Nigericinrespiration

-0.178

TRC10-150 ug/mL Triclosanrespiration

-0.319

TRZ10-25 ug/mL Thioridazinerespiration

-1.311

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.399

menadione6-10 ug/mL Menadionerespiration

0.338

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.625

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.051

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.890

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.780

NRP_1Non-replicating persistence stage 1dosRassociated

0.273

Amp0.2mg/mL AmpicillincellWall

-0.224

Cephalexin20-100 ug/mL CephalexincellWall

1.288

Cerulenin0.32-5 ug/mL CerulenincellWall

0.187

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.574

EMB10-20 ug/mL EthambutolcellWall

0.139

Eta12-40 ug/mL EthionamidecellWall

0.561

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.449

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.627

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.844

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.606

BZA0.12 mg/mL BenzamidearomaticAmides

-0.096

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.332

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.843

H2O24 mM hydrogen peroxideDNAdamaging

0.101

Levo10 ug/mL LevofloxacinDNAdamaging

0.404

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.573

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.757

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.177

UVUV-irradiationDNAdamaging

-0.869

ARP41-4 ug/mL Antitubercular compound ARP4?

0.485

Antimycin12.5-50 ug/mL Antimycin A?

-0.516

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.108

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.155

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.219

PA8240.2-2 ug/mL PA-824?

-1.540

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.189

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.813

Verapamil50 uM Verapamil?

-0.424

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.569

methoxatin10-20 ug/mL Methoxatin?