from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1272c/-

LFCtreatmentdescriptionclass of inhibitor

-0.880

Amikacinug/mL Amikacintranslation

-0.925

Cap5-10ug/mL Capreomycintranslation

0.020

Rox10-50 ug/mL Roxithromycintranslation

-0.377

SM2-5 ug/mL Streptomycintranslation

-1.212

Tet5-10 ug/mL Tetracyclinetranslation

0.448

Rif0.2-5ug/mL Rifampicintranscription

0.168

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.917

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.285

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.145

CPZ10-50 ug/mL Chlorpromazinerespiration

0.630

Clofazimine10-13 ug/mL Clofaziminerespiration

0.057

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.462

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.623

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.303

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.153

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.762

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.495

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.033

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.818

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.852

Nigericin50 uM Nigericinrespiration

-0.363

TRC10-150 ug/mL Triclosanrespiration

1.010

TRZ10-25 ug/mL Thioridazinerespiration

-0.928

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.891

menadione6-10 ug/mL Menadionerespiration

0.027

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.053

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.184

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.670

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.512

NRP_1Non-replicating persistence stage 1dosRassociated

-0.292

Amp0.2mg/mL AmpicillincellWall

0.632

Cephalexin20-100 ug/mL CephalexincellWall

-0.291

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.165

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.139

EMB10-20 ug/mL EthambutolcellWall

-0.787

Eta12-40 ug/mL EthionamidecellWall

-0.373

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.710

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.613

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.022

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.326

BZA0.12 mg/mL BenzamidearomaticAmides

0.913

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.430

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.909

H2O24 mM hydrogen peroxideDNAdamaging

-0.054

Levo10 ug/mL LevofloxacinDNAdamaging

0.841

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.119

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.316

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.550

UVUV-irradiationDNAdamaging

0.599

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.013

Antimycin12.5-50 ug/mL Antimycin A?

-1.216

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.234

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.539

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.099

PA8240.2-2 ug/mL PA-824?

-0.365

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.864

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.209

Verapamil50 uM Verapamil?

-0.455

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.989

methoxatin10-20 ug/mL Methoxatin?